Literature DB >> 22697594

Pharmacodynamic properties of antiplatelet agents: current knowledge and future perspectives.

Kallirroi I Kalantzi1, Maria E Tsoumani, Ioannis A Goudevenos, Alexandros D Tselepis.   

Abstract

Platelets play an important role in atherothrombotic disease. The currently available antiplatelet drugs target key steps of platelet activation including thromboxane A(2) synthesis, ADP-mediated signaling, and glycoprotein IIb/IIIa-mediated platelet aggregation. The improvement of our understanding on the pharmacokinetic and pharmacodynamic characteristics of these drugs enables the tailoring of the most appropriate anti-thrombotic therapy to the individual patient and risk situation in the daily clinical practice. However, current antiplatelet therapies are associated with increased bleeding risk. Thus, further research on platelet functions may give rise to numerous new antiplatelet agents with high anti-thrombotic efficiency and low adverse hemorrhagic side effects.

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Year:  2012        PMID： 22697594     DOI： 10.1586/ecp.12.19

Source DB:  PubMed          Journal:  Expert Rev Clin Pharmacol        ISSN： 1751-2433            Impact factor:   5.045


  10 in total

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Journal:  Acta Physiol (Oxf)       Date:  2015-05-04       Impact factor: 6.311

2.  P2Y12 Receptor Localizes in the Renal Collecting Duct and Its Blockade Augments Arginine Vasopressin Action and Alleviates Nephrogenic Diabetes Insipidus.

Authors:  Yue Zhang; Janos Peti-Peterdi; Christa E Müller; Noel G Carlson; Younis Baqi; David L Strasburg; Kristina M Heiney; Karie Villanueva; Donald E Kohan; Bellamkonda K Kishore
Journal:  J Am Soc Nephrol       Date:  2015-04-08       Impact factor: 10.121

3.  Microfludic platforms for the evaluation of anti-platelet agent efficacy under hyper-shear conditions associated with ventricular assist devices.

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Review 4.  Antithrombotic Agents and Cancer.

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Journal:  Cancers (Basel)       Date:  2018-07-31       Impact factor: 6.639

Review 5.  The Role of Eicosanoids in Alzheimer's Disease.

Authors:  Roger G Biringer
Journal:  Int J Environ Res Public Health       Date:  2019-07-18       Impact factor: 3.390

6.  The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species.

Authors:  Barbara Poniedziałek; Marek Siwulski; Adrian Wiater; Iwona Komaniecka; Anna Komosa; Monika Gąsecka; Zuzanna Magdziak; Mirosław Mleczek; Przemysław Niedzielski; Jędrzej Proch; Mariola Ropacka-Lesiak; Maciej Lesiak; Eliana Henao; Piotr Rzymski
Journal:  Nutrients       Date:  2019-12-12       Impact factor: 5.717

7.  Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib.

Authors:  Despoina Pantazi; Nikoleta Ntemou; Alexios Brentas; Dimitrios Alivertis; Konstantinos Skobridis; Alexandros D Tselepis
Journal:  Drug Des Devel Ther       Date:  2019-12-12       Impact factor: 4.162

8.  Inhibition of platelet adhesion, thrombus formation, and fibrin formation by a potent αIIbβ3 integrin inhibitor from ticks.

Authors:  Danique L van den Kerkhof; Magdolna Nagy; Kanin Wichapong; Sanne L N Brouns; Johan W M Heemskerk; Tilman M Hackeng; Ingrid Dijkgraaf
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9.  Efficacy and Safety of Adjunctive Cilostazol to Clopidogrel-Treated Diabetic Patients With Symptomatic Lower Extremity Artery Disease in the Prevention of Ischemic Vascular Events.

Authors:  Kallirroi Kalantzi; Nikolaos Tentolouris; Andreas J Melidonis; Styliani Papadaki; Michail Peroulis; Konstantinos A Amantos; George Andreopoulos; George I Bellos; Dimitrios Boutel; Magdalini Bristianou; Dimitrios Chrisis; Nikolaos A Dimitsikoglou; John Doupis; Chrysoula Georgopoulou; Stergios A Gkintikas; Styliani Iraklianou; Κonstantinos Kanellas; Kalliopi Kotsa; Theocharis Koufakis; Maria Kouroglou; Anastasios G Koutsovasilis; Leonidas Lanaras; Eirini Liouri; Charalampos Lixouriotis; Akrivi Lykoudi; Efthymia Mandalaki; Evanthia Papageorgiou; Nikolaos Papanas; Spyridon Rigas; Maria I Stamatelatou; Ioannis Triantafyllidis; Aikaterini Trikkalinou; Aikaterini N Tsouka; Ourania Zacharopoulou; Christos Zoupas; Ioannis Tsolakis; Alexandros D Tselepis
Journal:  J Am Heart Assoc       Date:  2020-12-17       Impact factor: 5.501

10.  Influence of genetic variations on levels of inflammatory markers of healthy subjects at baseline and one week after clopidogrel therapy; results of a preliminary study.

Authors:  Payman Shahabi; Gérard Siest; Bernard Herbeth; Daniel Lambert; Christine Masson; Jean-Sébastien Hulot; Sébastien Bertil; Pascale Gaussem; Sophie Visvikis-Siest
Journal:  Int J Mol Sci       Date:  2013-08-08       Impact factor: 5.923
  10 in total

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