Literature DB >> 226975

Interrupting the early region of polyoma virus DNA enhances tumorigenicity.

M A Israel, D T Simmons, S L Hourihan, W P Rowe, M A Martin.   

Abstract

The tumorigenicity of DNA from polyoma virus after cleavage with a variety of restriction enzymes was evaluated in suckling hamsters. Cleavage with enzymes that interrupt the region of the genome coding for the large tumor (T) antigen of polyoma virus markedly enhanced the tumorigenicity above that observed with DNA I of the virus. Cell lines established in vitro from tumors induced by polyoma virions, polyoma virus DNA I, or polyoma virus DNA that had been cleaved with restriction endonucleases in the early region all contain the polyoma virus middle and small T antigens but not the large T antigen of polyoma virus is not required for maintenance of the transformed state and probably not for initiation of tumorigenesis by viral DNA.

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Year:  1979        PMID： 226975      PMCID： PMC383903          DOI： 10.1073/pnas.76.8.3713

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  A SPECIFIC COMPLEMENT-FIXING ANTIGEN PRESENT IN SV40 TUMOR AND TRANSFORMED CELLS.

Authors:  P H BLACK; W P ROWE; H C TURNER; R J HUEBNER
Journal:  Proc Natl Acad Sci U S A       Date:  1963-12       Impact factor: 11.205

2.  SPECIFIC COMPLEMENT-FIXING ANTIGENS IN POLYOMA TUMORS AND TRANSFORMED CELLS.

Authors:  K HABEL
Journal:  Virology       Date:  1965-01       Impact factor: 3.616

3.  ISOLATION OF TEMPERATURE-SENSITIVE MUTANTS OF POLYOMA VIRUS.

Authors:  M FRIED
Journal:  Virology       Date:  1965-04       Impact factor: 3.616

4.  CELL-TRANSFORMING ABILITY OF A TEMPERATURE-SENSITIVE MUTANT OF POLYOMA VIRUS.

Authors:  M FRIED
Journal:  Proc Natl Acad Sci U S A       Date:  1965-03       Impact factor: 11.205

5.  Studies on cells rendered neoplastic by polyoma virus: the problem of the presence of virus-related materials.

Authors:  M VOGT; R DULBECCO
Journal:  Virology       Date:  1962-01       Impact factor: 3.616

6.  Multiple forms of polyoma virus tumor antigens from infected and transformed cells.

Authors:  D T Simmons; C Chang; M A Martin
Journal:  J Virol       Date:  1979-03       Impact factor: 5.103

7.  Biological activity of polyoma viral DNA in mice and hamsters.

Authors:  M A Israel; H W Chan; S L Hourihan; W P Rowe; M A Martin
Journal:  J Virol       Date:  1979-03       Impact factor: 5.103

8.  Localization of gene functions in polyoma virus DNA.

Authors:  J Feunteun; L Sompayrac; M Fluck; T Benjamin
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

9.  DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE.

Authors:  J H POPE; W P ROWE
Journal:  J Exp Med       Date:  1964-08-01       Impact factor: 14.307

10.  Studies of mouse polyoma virus infection. 1. Procedures for quantitation and detection of virus.

Authors:  W P ROWE; J W HARTLEY; J D ESTES; R J HUEBNER
Journal:  J Exp Med       Date:  1959-04-01       Impact factor: 14.307
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  22 in total

1.  Properties of cells transformed by the middle T-antigen-coding region of polyomavirus.

Authors:  C Priehs; K Friderici; L Winberry; M M Fluck
Journal:  J Virol       Date:  1986-01       Impact factor: 5.103

2.  Tumorigenic activity of cloned polyoma virus DNA in newborn rats.

Authors:  C Gélinas; L Bouchard; M Bastin
Journal:  Experientia       Date:  1981-10-15

3.  Requirement for the C-terminal region of middle T-antigen in cellular transformation by polyoma virus.

Authors:  U Novak; B E Griffin
Journal:  Nucleic Acids Res       Date:  1981-05-11       Impact factor: 16.971

4.  DNA sequences of polyoma virus early deletion mutants.

Authors:  N Smolar; B E Griffin
Journal:  J Virol       Date:  1981-06       Impact factor: 5.103

5.  Transformation of rat embryo fibroblasts by cloned polyoma virus DNA fragments containing only part of the early region.

Authors:  J A Hassell; W C Topp; D B Rifkin; P E Moreau
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

6.  Coding capacity of a 35 percent fragment of the polyoma virus genome is sufficient to initiate and maintain cellular transformation.

Authors:  U Novak; S M Dilworth; B E Griffin
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

7.  Phenotype of polyoma-induced hamster tumor cells lines.

Authors:  M A Israel; M A Martin; T Miyamura; K K Takemoto; D Rifkin; R Pollack
Journal:  J Virol       Date:  1980-07       Impact factor: 5.103

8.  A cloned polyoma DNA fragment representing the 5' half of the early gene region is oncogenic.

Authors:  K Chowdhury; S E Light; C F Garon; Y Ito; M A Israel
Journal:  J Virol       Date:  1980-11       Impact factor: 5.103

9.  Polyoma virus middle t antigen: a tumor progression factor.

Authors:  R Seif
Journal:  J Virol       Date:  1980-08       Impact factor: 5.103

10.  Stability of polyoma DNA sequences and virus-coded proteins during tumor formation.

Authors:  K Chowdhury; M L Meltzer; M A Israel
Journal:  J Virol       Date:  1982-03       Impact factor: 5.103
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