BACKGROUND: Alzheimer's disease (AD) is a chronic medical condition with symptoms that compromise patients' quality of life (QoL). The identification of the factor predicting QoL in AD is essential to develop more effective interventions. Recent research suggests that these factors could be different for the distinct informants. This study explores the QoL predictors considering three different sources of information: patients, caregivers, and healthcare staff. METHODS: In this cross-sectional study, a sample of 102 patients, their primary caregivers, and 15 members of the healthcare staff evaluated patients' QoL (QoL-AD Scale). Patients' and caregivers' demographic and clinical data (cognitive function, neuropsychiatric symptoms, depression, and caregivers' burden) were considered as QoL predictors. RESULTS: In multivariate-adjusted linear regression analyses, we observed that patients' ratings were mainly affected by their mood whereas caregivers' ratings were also negatively influenced by patients' irritability and burden. According to staff ratings, both psychotic symptoms and neuroleptics were associated with lower QoL. CONCLUSIONS: Our findings suggest that depression is the main variable related to patients' QoL and that more careful management of neuropsychiatric disorders is necessary. Both proxies' ratings are not equivalent to patients' reports in terms of predictors but they are complementary. Thus, a thorough QoL assessment should consider separately the perspective of the different informants.
BACKGROUND:Alzheimer's disease (AD) is a chronic medical condition with symptoms that compromise patients' quality of life (QoL). The identification of the factor predicting QoL in AD is essential to develop more effective interventions. Recent research suggests that these factors could be different for the distinct informants. This study explores the QoL predictors considering three different sources of information: patients, caregivers, and healthcare staff. METHODS: In this cross-sectional study, a sample of 102 patients, their primary caregivers, and 15 members of the healthcare staff evaluated patients' QoL (QoL-AD Scale). Patients' and caregivers' demographic and clinical data (cognitive function, neuropsychiatric symptoms, depression, and caregivers' burden) were considered as QoL predictors. RESULTS: In multivariate-adjusted linear regression analyses, we observed that patients' ratings were mainly affected by their mood whereas caregivers' ratings were also negatively influenced by patients' irritability and burden. According to staff ratings, both psychotic symptoms and neuroleptics were associated with lower QoL. CONCLUSIONS: Our findings suggest that depression is the main variable related to patients' QoL and that more careful management of neuropsychiatric disorders is necessary. Both proxies' ratings are not equivalent to patients' reports in terms of predictors but they are complementary. Thus, a thorough QoL assessment should consider separately the perspective of the different informants.
Authors: Maartje S Klapwijk; Monique A A Caljouw; Marjoleine J C Pieper; Jenny T van der Steen; Wilco P Achterberg Journal: Dement Geriatr Cogn Disord Date: 2016-09-27 Impact factor: 2.959
Authors: Cynthia S Hofman; Peter Makai; Jeanet W Blom; Han Boter; Bianca M Buurman; Marcel G M Olde Rikkert; Rogier Donders; René J F Melis Journal: PLoS One Date: 2015-03-04 Impact factor: 3.240
Authors: Marcia C Dourado; Maria F de Sousa; Raquel L Santos; José P Simões; Marcela L Nogueira; Tatiana T Belfort; Bianca Torres; Rachel Dias; Jerson Laks Journal: Braz J Psychiatry Date: 2016-01-08 Impact factor: 2.697
Authors: Cynthia S Hofman; Peter Makai; Han Boter; Bianca M Buurman; Anton J M de Craen; Marcel G M Olde Rikkert; Rogier A R T Donders; René J F Melis Journal: BMC Geriatr Date: 2014-04-18 Impact factor: 3.921