OBJECTIVES: We aimed to examine the discrepancy between patients and caregivers' ratings of quality of life in terms of accuracy and precision, and identify factors associated with it, in order to facilitate the use of this scale as dementia progresses. DESIGN: Cross-sectional analytic study. SETTING: Day care centres. PARTICIPANTS: Community-living patients with Alzheimer's disease in early or moderate stage and their principal caregivers. MEASUREMENTS: PARTICIPANTS rated patients' quality of life using DEMQOL. The discrepancy was assessed using the individual difference score and the residuals for each domain of DEMQOL. The scores on Mini-Mental State Examination, Geriatric Depression Scale, Neuropsychiatric Inventory, Clinical Insight Rating Scale, Cumulative Illness Rating Scale, Health Utilities Index Mark 3 and Zarit Burden Interview were considered as possible predictors of the discrepancy. RESULTS: A total of 276 subjects participated in the study (138 patients with Alzheimer's disease and their caregivers). Discrepancy measured by individual difference score was lower than that measured by the residuals. Burden and mood-related symptoms explained the positive differences and residuals, while pain, self-perceived depression and cognition determined the negative ones. CONCLUSIONS: Differences exist between patients and caregivers' perceptions about subjective states. The evaluations of each informant seem to be influenced by their own emotional state and the inner experience of the effects of the disease. Caregivers' ratings on DEMQOL could be useful to monitor the efficacy of any treatment whenever burden is low and patients have no great physical or emotional suffering.
OBJECTIVES: We aimed to examine the discrepancy between patients and caregivers' ratings of quality of life in terms of accuracy and precision, and identify factors associated with it, in order to facilitate the use of this scale as dementia progresses. DESIGN: Cross-sectional analytic study. SETTING: Day care centres. PARTICIPANTS: Community-living patients with Alzheimer's disease in early or moderate stage and their principal caregivers. MEASUREMENTS: PARTICIPANTS rated patients' quality of life using DEMQOL. The discrepancy was assessed using the individual difference score and the residuals for each domain of DEMQOL. The scores on Mini-Mental State Examination, Geriatric Depression Scale, Neuropsychiatric Inventory, Clinical Insight Rating Scale, Cumulative Illness Rating Scale, Health Utilities Index Mark 3 and Zarit Burden Interview were considered as possible predictors of the discrepancy. RESULTS: A total of 276 subjects participated in the study (138 patients with Alzheimer's disease and their caregivers). Discrepancy measured by individual difference score was lower than that measured by the residuals. Burden and mood-related symptoms explained the positive differences and residuals, while pain, self-perceived depression and cognition determined the negative ones. CONCLUSIONS: Differences exist between patients and caregivers' perceptions about subjective states. The evaluations of each informant seem to be influenced by their own emotional state and the inner experience of the effects of the disease. Caregivers' ratings on DEMQOL could be useful to monitor the efficacy of any treatment whenever burden is low and patients have no great physical or emotional suffering.
Authors: P Rinaldi; L Spazzafumo; R Mastriforti; P Mattioli; M Marvardi; M C Polidori; A Cherubini; G Abate; L Bartorelli; S Bonaiuto; A Capurso; D Cucinotta; M Gallucci; M Giordano; M Martorelli; G Masaraki; A Nieddu; C Pettenati; P Putzu; V A Tammaro; P F Tomassini; C Vergani; U Senin; P Mecocci Journal: Int J Geriatr Psychiatry Date: 2005-02 Impact factor: 3.485
Authors: Trevor Buckley; Elizabeth B Fauth; Ann Morrison; Joann Tschanz; Peter V Rabins; Kathleen W Piercy; Maria Norton; Constantine G Lyketsos Journal: Int Psychogeriatr Date: 2012-03-14 Impact factor: 3.878
Authors: A Hajek; T Luck; C Brettschneider; T Posselt; C Lange; B Wiese; S Steinmann; S Weyerer; J Werle; M Pentzek; A Fuchs; J Stein; H Bickel; E Mösch; M Wagner; K Heser; W Maier; J M Scherer; S G Riedel-Heller; H-H König Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Madison Niermeyer; Chad Gaudet; Paul Malloy; Irene Piryatinsky; Stephen Salloway; Petra Klinge; Athene Lee Journal: J Int Neuropsychol Soc Date: 2020-05-20 Impact factor: 2.892
Authors: Melanie T Gentry; Maria I Lapid; Jeremy Syrjanen; Kendrick Calvert; Samantha Hughes; Danielle Brushaber; Walter Kremers; Jessica Bove; Patrick Brannelly; Giovanni Coppola; Christina Dheel; Bradley Dickerson; Susan Dickinson; Kelley Faber; Julie Fields; Jamie Fong; Tatiana Foroud; Leah Forsberg; Ralitza Gavrilova; Deb Gearhart; Nupur Ghoshal; Jill Goldman; Jonathan Graff-Radford; Neill Graff-Radford; Murray Grossman; Dana Haley; Hilary Heuer; Ging-Yuek Hsiung; Edward Huey; David Irwin; David Jones; Lynne Jones; Kejal Kantarci; Anna Karydas; David Knopman; John Kornak; Joel Kramer; Walter Kukull; Diane Lucente; Codrin Lungu; Ian Mackenzie; Masood Manoochehri; Scott McGinnis; Bruce Miller; Rodney Pearlman; Len Petrucelli; Madeline Potter; Rosa Rademakers; Eliana Marisa Ramos; Katherine Rankin; Katya Rascovsky; Pheth Sengdy; Leslie Shaw; Nadine Tatton; Joanne Taylor; Arthur Toga; John Trojanowski; Sandra Weintraub; Bonnie Wong; Zbigniew Wszolek; Bradley F Boeve; Adam Boxer; Howard Rosen Journal: Alzheimers Dement Date: 2020-07-13 Impact factor: 21.566
Authors: Maria C J M Tol; Jurrian P Kuipers; Nienke W Willigenburg; Hanna C Willems; Rudolf W Poolman Journal: Health Qual Life Outcomes Date: 2021-01-27 Impact factor: 3.186