Literature DB >> 22696263

Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment.

So Jin Lee1, Myung Sook Huh, Seung Young Lee, Solki Min, Seulki Lee, Heebeom Koo, Jun-Uk Chu, Kyung Eun Lee, Hyesung Jeon, Yongseok Choi, Kuiwon Choi, Youngro Byun, Seo Young Jeong, Kinam Park, Kwangmeyung Kim, Ick Chan Kwon.   

Abstract

The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22696263     DOI： 10.1002/anie.201201390

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  30 in total

1.  Synthesis and characterization of glycol chitosan DNA nanoparticles for retinal gene delivery.

Authors:  Rajendra N Mitra; Zongchao Han; Miles Merwin; Muhammed Al Taai; Shannon M Conley; Muna I Naash
Journal:  ChemMedChem       Date:  2013-11-07       Impact factor: 3.466

Review 2.  Current Transport Systems and Clinical Applications for Small Interfering RNA (siRNA) Drugs.

Authors:  Fang Liu; Chunfang Wang; Yuantao Gao; Xiao Li; Feng Tian; Yongtao Zhang; Mingyang Fu; Pengfei Li; Yali Wang; Fei Wang
Journal:  Mol Diagn Ther       Date:  2018-10       Impact factor: 4.074

3.  Engineering Periodic shRNA for Enhanced Silencing Efficacy.

Authors:  Connie Wu; Kevin E Shopsowitz; Paula T Hammond
Journal:  Mol Ther       Date:  2016-04-07       Impact factor: 11.454

Review 4.  Application of polysaccharides for surface modification of nanomedicines.

Authors:  Kyung-Oh Doh; Yoon Yeo
Journal:  Ther Deliv       Date:  2012-12

5.  Supramolecular self-assembled nanoparticles mediate oral delivery of therapeutic TNF-α siRNA against systemic inflammation.

Authors:  Lichen Yin; Ziyuan Song; Qiuhao Qu; Kyung Hoon Kim; Nan Zheng; Catherine Yao; Isthier Chaudhury; Haoyu Tang; Nathan P Gabrielson; Fatih M Uckun; Jianjun Cheng
Journal:  Angew Chem Int Ed Engl       Date:  2013-04-22       Impact factor: 15.336

6.  Self-assembled nanoscale coordination polymers carrying siRNAs and cisplatin for effective treatment of resistant ovarian cancer.

Authors:  Chunbai He; Demin Liu; Wenbin Lin
Journal:  Biomaterials       Date:  2014-10-12       Impact factor: 12.479

7.  Fabrication of 14 different RNA nanoparticles for specific tumor targeting without accumulation in normal organs.

Authors:  Yi Shu; Farzin Haque; Dan Shu; Wei Li; Zhenqi Zhu; Malak Kotb; Yuri Lyubchenko; Peixuan Guo
Journal:  RNA       Date:  2013-04-19       Impact factor: 4.942

Review 8.  A Review on Chitosan's Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment.

Authors:  Rayssa de Sousa Victor; Adillys Marcelo da Cunha Santos; Bianca Viana de Sousa; Gelmires de Araújo Neves; Lisiane Navarro de Lima Santana; Romualdo Rodrigues Menezes
Journal:  Materials (Basel)       Date:  2020-11-06       Impact factor: 3.623

Review 9.  Polysaccharide-based nanoparticles for theranostic nanomedicine.

Authors:  M Swierczewska; H S Han; K Kim; J H Park; S Lee
Journal:  Adv Drug Deliv Rev       Date:  2015-11-27       Impact factor: 15.470

Review 10.  Delivery strategies and potential targets for siRNA in major cancer types.

Authors:  So Jin Lee; Min Ju Kim; Ick Chan Kwon; Thomas M Roberts
Journal:  Adv Drug Deliv Rev       Date:  2016-05-31       Impact factor: 15.470
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