| Literature DB >> 22694295 |
Noureddine El Aouad1, Guiomar Pérez-Moreno, Paula Sánchez, Juan Cantizani, Francisco Javier Ortiz-López, Jesús Martín, Víctor González-Menéndez, Luis M Ruiz-Pérez, Dolores González-Pacanowska, Francisca Vicente, Gerald Bills, Fernando Reyes.
Abstract
A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC(50) value of 11 μM.Entities:
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Year: 2012 PMID： 22694295 DOI： 10.1021/np3002942
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050