| Literature DB >> 22694269 |
Wenjun Zhang1, Zhong Liu, Sumei Li, Tingting Yang, Qingbo Zhang, Liang Ma, Xinpeng Tian, Haibo Zhang, Caiguo Huang, Si Zhang, Jianhua Ju, Yuemao Shen, Changsheng Zhang.
Abstract
A PCR-based screening approach led to the identification of a deep-sea-derived Streptomyces sp. SCSIO 03032 capable of producing new bisindole alkaloids spiroindimicins A-D (1-4). Structural elucidation of these compounds revealed the presence of unusual [5,6] or [5,5] spiro-ring containing skeletons. Spiroindimicins B-D (2-4) with a [5,5] spiro-ring exhibited moderate cytotoxicities against several cancer cell lines.Entities:
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Year: 2012 PMID： 22694269 DOI： 10.1021/ol301343n
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005