OBJECTIVES: Leg wound infection is a common complication after coronary artery bypass grafting (CABG). Suture contamination has been suggested as a mechanism of surgical site infections. VicrylPlus(®) is a polyglacitin suture coated with the antiseptic chemical substance Triclosan, which has been shown to inhibit the growth of Staphylococcus aureus in vitro. The first aim of the present study was to compare Vicryl Plus with conventional Vicryl(®) sutures with regard to leg wound infections following CABG. The second aim was to examine patient- and operative characteristics, which are assumed to predict leg wound infections. METHODS: After statistical calculations a priori, 328 CABG patients were prospectively randomized to leg wound closure with Vicryl Plus (164 patients) or conventional Vicryl sutures (164 patients). Incidences of leg wound infection and predictors of infection related to patient- and operative characteristics were examined. RESULTS: The incidence of leg wound infections was 10.4% (17/163) in the Vicryl group, and 10.0% (16/160) in the Vicryl Plus group (P = 1.00). Patients with leg wound infections had increased body mass index and prolonged extracorporeal circulation and aortic clamping time compared with patients without infections. CONCLUSIONS: In the present study, we report for the first time that Vicryl Plus did not reduce the incidence of leg wound infections in patients undergoing CABG. Obesity and prolonged time of extracorporeal circulation were both associated with the increased risk of infections. Currently, the clinical role and indication for the use of Vicryl Plus have yet to be defined.
RCT Entities:
OBJECTIVES: Leg wound infection is a common complication after coronary artery bypass grafting (CABG). Suture contamination has been suggested as a mechanism of surgical site infections. Vicryl Plus(®) is a polyglacitin suture coated with the antiseptic chemical substance Triclosan, which has been shown to inhibit the growth of Staphylococcus aureus in vitro. The first aim of the present study was to compare Vicryl Plus with conventional Vicryl(®) sutures with regard to leg wound infections following CABG. The second aim was to examine patient- and operative characteristics, which are assumed to predict leg wound infections. METHODS: After statistical calculations a priori, 328 CABG patients were prospectively randomized to leg wound closure with Vicryl Plus (164 patients) or conventional Vicryl sutures (164 patients). Incidences of leg wound infection and predictors of infection related to patient- and operative characteristics were examined. RESULTS: The incidence of leg wound infections was 10.4% (17/163) in the Vicryl group, and 10.0% (16/160) in the Vicryl Plus group (P = 1.00). Patients with leg wound infections had increased body mass index and prolonged extracorporeal circulation and aortic clamping time compared with patients without infections. CONCLUSIONS: In the present study, we report for the first time that Vicryl Plus did not reduce the incidence of leg wound infections in patients undergoing CABG. Obesity and prolonged time of extracorporeal circulation were both associated with the increased risk of infections. Currently, the clinical role and indication for the use of Vicryl Plus have yet to be defined.
Authors: Charles E Edmiston; Gary R Seabrook; Michael P Goheen; Candace J Krepel; Christopher P Johnson; Brian D Lewis; Kellie R Brown; Jonathan B Towne Journal: J Am Coll Surg Date: 2006-08-22 Impact factor: 6.113
Authors: Steven Goldman; Karen Zadina; Thomas Moritz; Theron Ovitt; Gulshan Sethi; Jack G Copeland; Lizy Thottapurathu; Barbara Krasnicka; Nancy Ellis; Robert J Anderson; William Henderson Journal: J Am Coll Cardiol Date: 2004-12-07 Impact factor: 24.094
Authors: Imran Ahmed; Adam Jonathan Boulton; Sana Rizvi; William Carlos; Edward Dickenson; N A Smith; Mike Reed Journal: BMJ Open Date: 2019-09-03 Impact factor: 2.692
Authors: X Wu; N Z Kubilay; J Ren; B Allegranzi; P Bischoff; B Zayed; D Pittet; J Li Journal: Eur J Clin Microbiol Infect Dis Date: 2016-09-02 Impact factor: 3.267
Authors: Paulo Samuel Santos; Marisa Santos; Alexandre Siciliano Colafranceschi; Andrea Nunes de Souza Pragana; Marcelo Goulart Correia; Heloisa Helena Simões; Fernando Alves Rocha; Maria Eduarda de Vasconcelos Soggia; Ana Paula Malta Samuel Santos; Annie de Azeredo Coutinho; Matheus Swarovsky Figueira; Bernardo Rangel Tura Journal: Braz J Cardiovasc Surg Date: 2019-12-01