| Literature DB >> 22691135 |
Yuki Nakamura1, Naohiko Yoshikai, Laurean Ilies, Eiichi Nakamura.
Abstract
A new diphosphine (POP) ligand bearing an alkoxide group allows us to synthesize partially fluorinated arenes. A nickel-catalyzed cross-coupling between a polyfluoroarene and an organozinc reagent in the presence of POP selectively produces a monosubstitution product. Aryl and alkylzinc reagents smoothly take part in the reaction. It is speculated that monosubstitution is the result of accelerated product expulsion from the product/catalyst complex.Entities:
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Year: 2012 PMID： 22691135 DOI： 10.1021/ol301195x
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005