| Literature DB >> 22686436 |
Aurélien Alix1, Claudia Lalli, Pascal Retailleau, Géraldine Masson.
Abstract
Metal-free chiral phosphoric acids and chiral calcium phosphates both catalyze highly enantio- and diastereoselective electrophilic α-bromination of enecarbamates to provide an atom-economical synthesis of enantioenriched vicinal haloamines. Either enantiomer can be formed in good yield with excellent diastereo- and enantioselectivity simply by switching the catalyst from a phosphoric acid to its calcium salt.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22686436 DOI： 10.1021/ja304095z
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419