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Literature DB >> 22686334

Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances.

Wei-Ye Liu¹, Zhi-Bin Wang, Li-Chao Zhang, Xin Wei, Ling Li.

Abstract

Blood-brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic substance in and out of the central nervous system (CNS), and plays a crucial role in maintaining a stable circumstance of the CNS. Tight junctions among adjacent cells form the basic structure of BBB to limiting paracellular permeability. In the present review, the constituents of tight junction proteins are depicted in detail, together with the regulation of tight junction under stimulation and in pathological conditions. Tight junction modulators are also discussed.

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Year: 2012 PMID： 22686334 PMCID： PMC6493516 DOI： 10.1111/j.1755-5949.2012.00340.x

Source DB: PubMed Journal: CNS Neurosci Ther ISSN： 1755-5930 Impact factor: 5.243

104 in total

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10. Role of microRNA29b in blood-brain barrier dysfunction during hyperhomocysteinemia: an epigenetic mechanism.

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