Literature DB >> 22684058

Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.

Jing Hou1, Kamila Wojciechowska, Heping Zheng, Maksymilian Chruszcz, David R Cooper, Marcin Cymborowski, Tatiana Skarina, Elena Gordon, Haibin Luo, Alexei Savchenko, Wladek Minor.   

Abstract

The crystal structure of a short-chain dehydrogenase/reductase from Bacillus anthracis strain `Ames Ancestor' complexed with NADP has been determined and refined to 1.87 Å resolution. The structure of the enzyme consists of a Rossmann fold composed of seven parallel β-strands sandwiched by three α-helices on each side. An NADP molecule from an endogenous source is bound in the conserved binding pocket in the syn conformation. The loop region responsible for binding another substrate forms two perpendicular short helices connected by a sharp turn.

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Year:  2012        PMID： 22684058      PMCID： PMC3370898          DOI： 10.1107/S1744309112017939

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  46 in total

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9.  Automated MAD and MIR structure solution.

Authors:  T C Terwilliger; J Berendzen
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10.  Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis.

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Journal:  J Mol Biol       Date:  2002-07-05       Impact factor: 5.469
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