Literature DB >> 22683805

Open PHACTS: semantic interoperability for drug discovery.

Antony J Williams1, Lee Harland, Paul Groth, Stephen Pettifer, Christine Chichester, Egon L Willighagen, Chris T Evelo, Niklas Blomberg, Gerhard Ecker, Carole Goble, Barend Mons.   

Abstract

Open PHACTS is a public-private partnership between academia, publishers, small and medium sized enterprises and pharmaceutical companies. The goal of the project is to deliver and sustain an 'open pharmacological space' using and enhancing state-of-the-art semantic web standards and technologies. It is focused on practical and robust applications to solve specific questions in drug discovery research. OPS is intended to facilitate improvements in drug discovery in academia and industry and to support open innovation and in-house non-public drug discovery research. This paper lays out the challenges and how the Open PHACTS project is hoping to address these challenges technically and socially.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Mesh:

Year:  2012        PMID: 22683805     DOI: 10.1016/j.drudis.2012.05.016

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  102 in total

1.  Privacy-preserving search for chemical compound databases.

Authors:  Kana Shimizu; Koji Nuida; Hiromi Arai; Shigeo Mitsunari; Nuttapong Attrapadung; Michiaki Hamada; Koji Tsuda; Takatsugu Hirokawa; Jun Sakuma; Goichiro Hanaoka; Kiyoshi Asai
Journal:  BMC Bioinformatics       Date:  2015-12-09       Impact factor: 3.169

2.  The ChEMBL database as linked open data.

Authors:  Egon L Willighagen; Andra Waagmeester; Ola Spjuth; Peter Ansell; Antony J Williams; Valery Tkachenko; Janna Hastings; Bin Chen; David J Wild
Journal:  J Cheminform       Date:  2013-05-08       Impact factor: 5.514

3.  Many InChIs and quite some feat.

Authors:  Wendy A Warr
Journal:  J Comput Aided Mol Des       Date:  2015-06-17       Impact factor: 3.686

Review 4.  Knowledge Representation and Management: a Linked Data Perspective.

Authors:  M Barros; F M Couto
Journal:  Yearb Med Inform       Date:  2016-11-10

Review 5.  Biomarkers, designs, and interpretations of resting-state fMRI in translational pharmacological research: A review of state-of-the-Art, challenges, and opportunities for studying brain chemistry.

Authors:  Najmeh Khalili-Mahani; Serge A R B Rombouts; Matthias J P van Osch; Eugene P Duff; Felix Carbonell; Lisa D Nickerson; Lino Becerra; Albert Dahan; Alan C Evans; Jean-Paul Soucy; Richard Wise; Alex P Zijdenbos; Joop M van Gerven
Journal:  Hum Brain Mapp       Date:  2017-02-01       Impact factor: 5.038

Review 6.  Shifting from the single to the multitarget paradigm in drug discovery.

Authors:  José L Medina-Franco; Marc A Giulianotti; Gregory S Welmaker; Richard A Houghten
Journal:  Drug Discov Today       Date:  2013-01-20       Impact factor: 7.851

7.  The Royal Society of Chemistry and the delivery of chemistry data repositories for the community.

Authors:  Antony Williams; Valery Tkachenko
Journal:  J Comput Aided Mol Des       Date:  2014-08-03       Impact factor: 3.686

8.  Data sharing matters.

Authors:  Wendy A Warr
Journal:  J Comput Aided Mol Des       Date:  2014-01-17       Impact factor: 3.686

9.  Integrative knowledge management to enhance pharmaceutical R&D.

Authors:  Maria Marti-Solano; Ewan Birney; Antoine Bril; Oscar Della Pasqua; Hiroaki Kitano; Barend Mons; Ioannis Xenarios; Ferran Sanz
Journal:  Nat Rev Drug Discov       Date:  2014-04       Impact factor: 84.694

10.  Many approved drugs have bioactive analogs with different target annotations.

Authors:  Ye Hu; Eugen Lounkine; Jürgen Bajorath
Journal:  AAPS J       Date:  2014-05-29       Impact factor: 4.009

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