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Literature DB >> 22683718

Leishmania virulence factors: focus on the metalloprotease GP63.

Martin Olivier¹, Vanessa Diniz Atayde, Amandine Isnard, Kasra Hassani, Marina Tiemi Shio.

Abstract

Parasites of Leishmania genus have developed elegant strategies permitting them to evade the innate immune response upon their initial interaction with macrophages. Their capacity to dodge the induction of macrophages microbicidal functions was found to correlate with the alteration of several signalling pathways regulating those latter. In this review, the role of the Leishmania GP63 as a critical virulence factor influencing macrophage physiology will be discussed.

Entities: Disease Gene

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Substances：

Year: 2012 PMID： 22683718 DOI： 10.1016/j.micinf.2012.05.014

Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700

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Cited

70 in total

1. Leishmania donovani Lipophosphoglycan Increases Macrophage-Dependent Chemotaxis of CXCR6-Expressing Cells via CXCL16 Induction.

Authors: Visnu Chaparro; Louis-Philippe Leroux; Aude Zimmermann; Armando Jardim; Brent Johnston; Albert Descoteaux; Maritza Jaramillo
Journal: Infect Immun Date: 2019-04-23 Impact factor: 3.441

2. LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasites.

Authors: Sandra Carvalho; Rosa Barreira da Silva; Ali Shawki; Helena Castro; Márcia Lamy; David Eide; Vítor Costa; Bryan Mackenzie; Ana M Tomás
Journal: Mol Microbiol Date: 2015-03-11 Impact factor: 3.501

Review 3. Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

Authors: Advait S Nagle; Shilpi Khare; Arun Babu Kumar; Frantisek Supek; Andriy Buchynskyy; Casey J N Mathison; Naveen Kumar Chennamaneni; Nagendar Pendem; Frederick S Buckner; Michael H Gelb; Valentina Molteni
Journal: Chem Rev Date: 2014-11-03 Impact factor: 60.622

Leishmania virulence factors: focus on the metalloprotease GP63.

1. Leishmania donovani Lipophosphoglycan Increases Macrophage-Dependent Chemotaxis of CXCR6-Expressing Cells via CXCL16 Induction.

2. LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasites.

Review 3. Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

4. Characterization of the Protein Tyrosine Phosphatase LmPRL-1 Secreted by Leishmania major via the Exosome Pathway.

5. Mechanisms of immune evasion in leishmaniasis.

6. Leishmania braziliensis prostaglandin F_2α synthase impacts host infection.

Review 7. Co-opting oxylipin signals in microbial disease.

8. Plasmenylethanolamine synthesis in Leishmania major.

9. Exosome Secretion by the Parasitic Protozoan Leishmania within the Sand Fly Midgut.

10. GTPase Sar1 regulates the trafficking and secretion of the virulence factor gp63 in Leishmania.