BACKGROUND: Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown. METHODS: We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from the general population. RESULTS: We found that all three genes contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. CONCLUSIONS: The identified region contained white matter pathways connecting the middle temporal gyrus with the inferior parietal lobe. The finding links previous neuroimaging and genetic results and proposes a mechanism underlying variability in reading ability in both normal and impaired readers.
BACKGROUND: Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown. METHODS: We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from the general population. RESULTS: We found that all three genes contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. CONCLUSIONS: The identified region contained white matter pathways connecting the middle temporal gyrus with the inferior parietal lobe. The finding links previous neuroimaging and genetic results and proposes a mechanism underlying variability in reading ability in both normal and impaired readers.
Authors: Jessica Becker; Darina Czamara; Tom S Scerri; Franck Ramus; Valéria Csépe; Joel B Talcott; John Stein; Andrew Morris; Kerstin U Ludwig; Per Hoffmann; Ferenc Honbolygó; Dénes Tóth; Fabien Fauchereau; Caroline Bogliotti; Stéphanie Iannuzzi; Yves Chaix; Sylviane Valdois; Catherine Billard; Florence George; Isabelle Soares-Boucaud; Christophe-Loïc Gérard; Sanne van der Mark; Enrico Schulz; Anniek Vaessen; Urs Maurer; Kaisa Lohvansuu; Heikki Lyytinen; Marco Zucchelli; Daniel Brandeis; Leo Blomert; Paavo H T Leppänen; Jennifer Bruder; Anthony P Monaco; Bertram Müller-Myhsok; Juha Kere; Karin Landerl; Markus M Nöthen; Gerd Schulte-Körne; Silvia Paracchini; Myriam Peyrard-Janvid; Johannes Schumacher Journal: Eur J Hum Genet Date: 2013-09-11 Impact factor: 4.246
Authors: Jason D Yeatman; Robert F Dougherty; Michal Ben-Shachar; Brian A Wandell Journal: Proc Natl Acad Sci U S A Date: 2012-10-08 Impact factor: 11.205
Authors: Amaia Carrion-Castillo; Ben Maassen; Barbara Franke; Angelien Heister; Marlies Naber; Aryan van der Leij; Clyde Francks; Simon E Fisher Journal: Eur J Hum Genet Date: 2017-01-11 Impact factor: 4.246
Authors: Cecilia Marino; Paola Scifo; Pasquale A Della Rosa; Sara Mascheretti; Andrea Facoetti; Maria L Lorusso; Roberto Giorda; Monica Consonni; Andrea Falini; Massimo Molteni; Jeffrey R Gruen; Daniela Perani Journal: Cortex Date: 2014-05-09 Impact factor: 4.027
Authors: Zachary A Miller; Maria Luisa Mandelli; Katherine P Rankin; Maya L Henry; Miranda C Babiak; Darvis T Frazier; Iryna V Lobach; Brianne M Bettcher; Teresa Q Wu; Gil D Rabinovici; Neill R Graff-Radford; Bruce L Miller; Maria Luisa Gorno-Tempini Journal: Brain Date: 2013-09-20 Impact factor: 13.501