PURPOSE: We sought to visualize the aqueous outflow system in 3 dimensions (3D) in living human eyes, and to investigate the use of commercially available spectral-domain optical coherence tomographic (SD-OCT) systems for this purpose. DESIGN: Prospective, observational study. PARTICIPANTS: One randomly determined eye in each of 6 normal healthy subjects was included. TESTING: We performed 3D SD-OCT imaging of the aqueous humor outflow structures with 2 devices: The Cirrus HD-OCT and the Bioptigen SDOIS. MAIN OUTCOME MEASURES: We created 3D virtual castings of Schlemm's canal (SC) and more distal outflow structures from scan data from each device. RESULTS: Virtual casting of the SC provided visualization of more aqueous vessels branching from SC than could be located by interrogating the 2-dimensional (2D) image stack. Similarly, virtual casting of distal structures allowed visualization of large and small aqueous outflow channel networks that could not be appreciated with conventional 2D visualization. CONCLUSIONS: The outflow pathways from SC to the superficial vasculature can be identified and tracked in living human eyes using commercially available SD-OCT.
PURPOSE: We sought to visualize the aqueous outflow system in 3 dimensions (3D) in living human eyes, and to investigate the use of commercially available spectral-domain optical coherence tomographic (SD-OCT) systems for this purpose. DESIGN: Prospective, observational study. PARTICIPANTS: One randomly determined eye in each of 6 normal healthy subjects was included. TESTING: We performed 3D SD-OCT imaging of the aqueous humor outflow structures with 2 devices: The Cirrus HD-OCT and the Bioptigen SDOIS. MAIN OUTCOME MEASURES: We created 3D virtual castings of Schlemm's canal (SC) and more distal outflow structures from scan data from each device. RESULTS: Virtual casting of the SC provided visualization of more aqueous vessels branching from SC than could be located by interrogating the 2-dimensional (2D) image stack. Similarly, virtual casting of distal structures allowed visualization of large and small aqueous outflow channel networks that could not be appreciated with conventional 2D visualization. CONCLUSIONS: The outflow pathways from SC to the superficial vasculature can be identified and tracked in living human eyes using commercially available SD-OCT.
Authors: Larry Kagemann; Gadi Wollstein; Hiroshi Ishikawa; Ian A Sigal; Lindsey S Folio; Juan Xu; Haiyan Gong; Joel S Schuman Journal: Exp Eye Res Date: 2011-04-15 Impact factor: 3.467
Authors: Larry Kagemann; Gadi Wollstein; Hiroshi Ishikawa; Richard A Bilonick; Peter M Brennen; Lindsey S Folio; Michelle L Gabriele; Joel S Schuman Journal: Invest Ophthalmol Vis Sci Date: 2010-03-17 Impact factor: 4.799
Authors: Larry Kagemann; Hiroshi Ishikawa; Gadi Wollstein; Michelle Gabriele; Joel S Schuman Journal: Opt Express Date: 2009-03-02 Impact factor: 3.894
Authors: Ian A Sigal; Jonathan L Grimm; Ning-Jiun Jan; Korey Reid; Don S Minckler; Donald J Brown Journal: Invest Ophthalmol Vis Sci Date: 2014-01-02 Impact factor: 4.799
Authors: Alex S Huang; Akram Belghith; Anna Dastiridou; Vikas Chopra; Linda M Zangwill; Robert N Weinreb Journal: J Biomed Opt Date: 2017-06-01 Impact factor: 3.170
Authors: Frank Brodie; Michael Repka; Stephen Allan Burns; S Grace Prakalapakorn; Christie Morse; Joel S Schuman; Michael R Duenas; Natalie Afshari; John S Pollack; Jennifer E Thorne; Albert Vitale; H Nida Sen; David Myung; Mark S Blumenkranz; Elmer Tu; Daniel X Hammer; Michelle Tarver; Bradley Cunningham; Larry Kagemann; SriniVas Sadda; David Sarraf; Glenn J Jaffe; Malvina Eydelman Journal: JAMA Ophthalmol Date: 2021-01-01 Impact factor: 7.389
Authors: Guorong Li; Sina Farsiu; Stephanie J Chiu; Pedro Gonzalez; Elke Lütjen-Drecoll; Darryl R Overby; W Daniel Stamer Journal: Invest Ophthalmol Vis Sci Date: 2014-03-04 Impact factor: 4.799