Literature DB >> 22682216

HOT models in flux: mitochondrial glucose oxidation fuels glioblastoma growth.

Paul S Mischel1.   

Abstract

Cancer cells in culture obtain ATP and biosynthetic precursors primarily by aerobic glycolysis, not by mitochondrial glucose oxidation. In this issue of Cell Metabolism, Marin-Valencia et al. (2012) demonstrate that glioblastoma, an aggressive and, in culture, highly glycolytic cancer, primarily uses glucose oxidation to meet energetic and biosynthetic demands in vivo.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22682216      PMCID： PMC3376384          DOI： 10.1016/j.cmet.2012.05.004

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  9 in total

1.  New strategies in the molecular targeting of glioblastoma: how do you hit a moving target?

Authors:  Timothy F Cloughesy; Paul S Mischel
Journal:  Clin Cancer Res       Date:  2011-01-01       Impact factor: 12.531

2.  Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.

Authors:  Christian M Metallo; Paulo A Gameiro; Eric L Bell; Katherine R Mattaini; Juanjuan Yang; Karsten Hiller; Christopher M Jewell; Zachary R Johnson; Darrell J Irvine; Leonard Guarente; Joanne K Kelleher; Matthew G Vander Heiden; Othon Iliopoulos; Gregory Stephanopoulos
Journal:  Nature       Date:  2011-11-20       Impact factor: 49.962

3.  Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.

Authors:  Isaac Marin-Valencia; Chendong Yang; Tomoyuki Mashimo; Steve Cho; Hyeonman Baek; Xiao-Li Yang; Kartik N Rajagopalan; Melissa Maddie; Vamsidhara Vemireddy; Zhenze Zhao; Ling Cai; Levi Good; Benjamin P Tu; Kimmo J Hatanpaa; Bruce E Mickey; José M Matés; Juan M Pascual; Elizabeth A Maher; Craig R Malloy; Ralph J Deberardinis; Robert M Bachoo
Journal:  Cell Metab       Date:  2012-06-06       Impact factor: 27.287

4.  Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.

Authors:  Piyush B Gupta; Christine M Fillmore; Guozhi Jiang; Sagi D Shapira; Kai Tao; Charlotte Kuperwasser; Eric S Lander
Journal:  Cell       Date:  2011-08-19       Impact factor: 41.582

5.  Metabolic modulation of glioblastoma with dichloroacetate.

Authors:  E D Michelakis; G Sutendra; P Dromparis; L Webster; A Haromy; E Niven; C Maguire; T-L Gammer; J R Mackey; D Fulton; B Abdulkarim; M S McMurtry; K C Petruk
Journal:  Sci Transl Med       Date:  2010-05-12       Impact factor: 17.956

6.  Metabolism of [U-13 C]glucose in human brain tumors in vivo.

Authors:  Elizabeth A Maher; Isaac Marin-Valencia; Robert M Bachoo; Tomoyuki Mashimo; Jack Raisanen; Kimmo J Hatanpaa; Ashish Jindal; F Mark Jeffrey; Changho Choi; Christopher Madden; Dana Mathews; Juan M Pascual; Bruce E Mickey; Craig R Malloy; Ralph J DeBerardinis
Journal:  NMR Biomed       Date:  2012-03-15       Impact factor: 4.044

Review 7.  Otto Warburg's contributions to current concepts of cancer metabolism.

Authors:  Willem H Koppenol; Patricia L Bounds; Chi V Dang
Journal:  Nat Rev Cancer       Date:  2011-04-14       Impact factor: 60.716

Review 8.  Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Authors:  Matthew G Vander Heiden; Lewis C Cantley; Craig B Thompson
Journal:  Science       Date:  2009-05-22       Impact factor: 47.728

9.  Reductive carboxylation supports growth in tumour cells with defective mitochondria.

Authors:  Andrew R Mullen; William W Wheaton; Eunsook S Jin; Pei-Hsuan Chen; Lucas B Sullivan; Tzuling Cheng; Youfeng Yang; W Marston Linehan; Navdeep S Chandel; Ralph J DeBerardinis
Journal:  Nature       Date:  2011-11-20       Impact factor: 69.504
  9 in total
  8 in total

Review 1.  The ketogenic diet for the treatment of malignant glioma.

Authors:  Eric C Woolf; Adrienne C Scheck
Journal:  J Lipid Res       Date:  2014-02-06       Impact factor: 5.922

Review 2.  Brain Tumor-Related Epilepsy: a Current Review of the Etiologic Basis and Diagnostic and Treatment Approaches.

Authors:  Jeffrey M Politsky
Journal:  Curr Neurol Neurosci Rep       Date:  2017-09       Impact factor: 5.081

3.  Targeting cancer cell metabolism: The combination of metformin and 2-Deoxyglucose regulates apoptosis in ovarian cancer cells via p38 MAPK/JNK signaling pathway.

Authors:  Jie Zhu; Ya Zheng; Haiyan Zhang; Hong Sun
Journal:  Am J Transl Res       Date:  2016-11-15       Impact factor: 4.060

4.  Dual-targeting of aberrant glucose metabolism in glioblastoma.

Authors:  Han Shen; Stephanie Decollogne; Pierre J Dilda; Eric Hau; Sylvia A Chung; Peter P Luk; Philip J Hogg; Kerrie L McDonald
Journal:  J Exp Clin Cancer Res       Date:  2015-02-05

5.  Development and Characterization of Methylene Blue Oleate Salt-Loaded Polymeric Nanoparticles and their Potential Application as a Treatment for Glioblastoma.

Authors:  J M Castañeda-Gill; A P Ranjan; J K Vishwanatha
Journal:  J Nanomed Nanotechnol       Date:  2017-07-31

6.  Bioenergetic modulators hamper cancer cell viability and enhance response to chemotherapy.

Authors:  Diana Tavares-Valente; Sara Granja; Fátima Baltazar; Odília Queirós
Journal:  J Cell Mol Med       Date:  2018-05-29       Impact factor: 5.295

Review 7.  Use of MRI, metabolomic, and genomic biomarkers to identify mechanisms of chemoresistance in glioma.

Authors:  Cathy W Levenson; Thomas J Morgan; Pamela D Twigg; Timothy M Logan; Victor D Schepkin
Journal:  Cancer Drug Resist       Date:  2019-09-19

8.  ABT-263 enhances sensitivity to metformin and 2-deoxyglucose in pediatric glioma by promoting apoptotic cell death.

Authors:  Jane Levesley; Lynette Steele; Claire Taylor; Priyank Sinha; Sean E Lawler
Journal:  PLoS One       Date:  2013-05-17       Impact factor: 3.240
  8 in total

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