BACKGROUND: The number of women diagnosed with ductal carcinoma in situ (DCIS) is increasing. Although many eventually develop a second breast cancer (SBC), little is known about the characteristics of SBCs. The authors described the characteristics of SBC and examined associations between the pathologic features of SBC and index DCIS cases. METHODS: Women were identified in the National Comprehensive Cancer Network Outcomes Database who were diagnosed with DCIS from 1997 to 2008 and underwent lumpectomy and who subsequently developed SBC (including DCIS or invasive disease that occurred in the ipsilateral or contralateral breast). The Fisher exact test and the Spearman test were used to examine associations between the pathologic characteristics of SBC and index DCIS cases. RESULTS: Among 2636 women who underwent lumpectomy for DCIS, 150 (5.7%) experienced an SBC after a median of 55.5 months of follow-up. Of these 150 women, 105 (70%) received adjuvant radiotherapy, and 50 (33.3%) received tamoxifen for their index DCIS. SBCs were ipsilateral in 54.7% of women and invasive in 50.7% of women. Among the index DCIS cases, 60.6% were estrogen receptor (ER)-positive, and 54% were high grade, whereas 77.5% of SBCs were ER-positive, and 48.2% were high grade. Tumor grade (P = .003) and ER status (P = .02) were associated significantly between index DCIS and SBC, whereas tumor size was not (P = .87). CONCLUSIONS: After breast conservation for DCIS, SBC in either breast exhibited pathologic characteristics similar to the index DCIS, suggesting that women with DCIS may be at risk for developing subsequent breast cancers of a similar phenotype.
BACKGROUND: The number of women diagnosed with ductal carcinoma in situ (DCIS) is increasing. Although many eventually develop a second breast cancer (SBC), little is known about the characteristics of SBCs. The authors described the characteristics of SBC and examined associations between the pathologic features of SBC and index DCIS cases. METHODS:Women were identified in the National Comprehensive Cancer Network Outcomes Database who were diagnosed with DCIS from 1997 to 2008 and underwent lumpectomy and who subsequently developed SBC (including DCIS or invasive disease that occurred in the ipsilateral or contralateral breast). The Fisher exact test and the Spearman test were used to examine associations between the pathologic characteristics of SBC and index DCIS cases. RESULTS: Among 2636 women who underwent lumpectomy for DCIS, 150 (5.7%) experienced an SBC after a median of 55.5 months of follow-up. Of these 150 women, 105 (70%) received adjuvant radiotherapy, and 50 (33.3%) received tamoxifen for their index DCIS. SBCs were ipsilateral in 54.7% of women and invasive in 50.7% of women. Among the index DCIS cases, 60.6% were estrogen receptor (ER)-positive, and 54% were high grade, whereas 77.5% of SBCs were ER-positive, and 48.2% were high grade. Tumor grade (P = .003) and ER status (P = .02) were associated significantly between index DCIS and SBC, whereas tumor size was not (P = .87). CONCLUSIONS: After breast conservation for DCIS, SBC in either breast exhibited pathologic characteristics similar to the index DCIS, suggesting that women with DCIS may be at risk for developing subsequent breast cancers of a similar phenotype.
Authors: Nina Bijker; Philip Meijnen; Johannes L Peterse; Jan Bogaerts; Irène Van Hoorebeeck; Jean-Pierre Julien; Massimiliano Gennaro; Philippe Rouanet; Antoine Avril; Ian S Fentiman; Harry Bartelink; Emiel J Th Rutgers Journal: J Clin Oncol Date: 2006-06-26 Impact factor: 44.544
Authors: William E Sumner; Leonidas G Koniaris; Sarah E Snell; Seth Spector; Jodeen Powell; Eli Avisar; Frederick Moffat; Alan S Livingstone; Dido Franceschi Journal: Ann Surg Oncol Date: 2007-01-24 Impact factor: 5.344
Authors: Benjamin D Smith; Bruce G Haffty; Thomas A Buchholz; Grace L Smith; Deron H Galusha; Justin E Bekelman; Cary P Gross Journal: J Natl Cancer Inst Date: 2006-09-20 Impact factor: 13.506
Authors: Stefan O Emdin; Bengt Granstrand; Anita Ringberg; Kerstin Sandelin; Lars-Gunnar Arnesson; Hans Nordgren; Harald Anderson; Hans Garmo; Lars Holmberg; Arne Wallgren Journal: Acta Oncol Date: 2006 Impact factor: 4.089
Authors: Tina W F Yen; Henry M Kuerer; Rebecca A Ottesen; Layla Rouse; Joyce C Niland; Stephen B Edge; Richard L Theriault; Jane C Weeks Journal: J Clin Oncol Date: 2007-06-18 Impact factor: 44.544
Authors: Stephanie G MacAusland; Jaroslaw T Hepel; Frank K Chong; Shira L Galper; Jennifer S Gass; Robin Ruthazer; David E Wazer Journal: Cancer Date: 2007-12-15 Impact factor: 6.860
Authors: N Sänger; K Engels; A Graf; E Ruckhäberle; K E Effenberger; T Fehm; U Holtrich; S Becker; T Karn Journal: Geburtshilfe Frauenheilkd Date: 2014-11 Impact factor: 2.915
Authors: R Souchon; M-L Sautter-Bihl; F Sedlmayer; W Budach; J Dunst; P Feyer; R Fietkau; W Haase; W Harms; F Wenz; R Sauer Journal: Strahlenther Onkol Date: 2014-01 Impact factor: 3.621
Authors: Michael J Hassett; Wei Jiang; Laurel A Habel; Larissa Nekhlyudov; Ninah Achacoso; Luana Acton; Stuart J Schnitt; Deb Schrag; Rinaa S Punglia Journal: Breast Cancer Res Treat Date: 2016-02-03 Impact factor: 4.872
Authors: Yasuaki Sagara; Rachel A Freedman; Ines Vaz-Luis; Melissa Anne Mallory; Stephanie M Wong; Fatih Aydogan; Stephen DeSantis; William T Barry; Mehra Golshan Journal: J Clin Oncol Date: 2016-02-01 Impact factor: 44.544
Authors: Christos Petridis; Mark N Brook; Vandna Shah; Kelly Kohut; Patricia Gorman; Michele Caneppele; Dina Levi; Efterpi Papouli; Nick Orr; Angela Cox; Simon S Cross; Isabel Dos-Santos-Silva; Julian Peto; Anthony Swerdlow; Minouk J Schoemaker; Manjeet K Bolla; Qin Wang; Joe Dennis; Kyriaki Michailidou; Javier Benitez; Anna González-Neira; Daniel C Tessier; Daniel Vincent; Jingmei Li; Jonine Figueroa; Vessela Kristensen; Anne-Lise Borresen-Dale; Penny Soucy; Jacques Simard; Roger L Milne; Graham G Giles; Sara Margolin; Annika Lindblom; Thomas Brüning; Hiltrud Brauch; Melissa C Southey; John L Hopper; Thilo Dörk; Natalia V Bogdanova; Maria Kabisch; Ute Hamann; Rita K Schmutzler; Alfons Meindl; Hermann Brenner; Volker Arndt; Robert Winqvist; Katri Pylkäs; Peter A Fasching; Matthias W Beckmann; Jan Lubinski; Anna Jakubowska; Anna Marie Mulligan; Irene L Andrulis; Rob A E M Tollenaar; Peter Devilee; Loic Le Marchand; Christopher A Haiman; Arto Mannermaa; Veli-Matti Kosma; Paolo Radice; Paolo Peterlongo; Frederik Marme; Barbara Burwinkel; Carolien H M van Deurzen; Antoinette Hollestelle; Nicola Miller; Michael J Kerin; Diether Lambrechts; Giuseppe Floris; Jelle Wesseling; Henrik Flyger; Stig E Bojesen; Song Yao; Christine B Ambrosone; Georgia Chenevix-Trench; Thérèse Truong; Pascal Guénel; Anja Rudolph; Jenny Chang-Claude; Heli Nevanlinna; Carl Blomqvist; Kamila Czene; Judith S Brand; Janet E Olson; Fergus J Couch; Alison M Dunning; Per Hall; Douglas F Easton; Paul D P Pharoah; Sarah E Pinder; Marjanka K Schmidt; Ian Tomlinson; Rebecca Roylance; Montserrat García-Closas; Elinor J Sawyer Journal: Breast Cancer Res Date: 2016-02-17 Impact factor: 6.466