PURPOSE: Tobacco and alcohol use are well-known risk factors for squamous cell carcinoma of the head and neck (SCCHN), but there has been little examination of disparities in SCCHN and racial patterns of tobacco and alcohol use, especially for African-Americans. The Carolina Head and Neck Cancer Study, a population-based case-control study, was utilized to determine whether relationships between tobacco and alcohol use and SCCHN differed by race. METHODS: Using a rapid case ascertainment system, cases were recruited from 46 contiguous counties in North Carolina from 2002 to 2006. Controls, selected from motor vehicle records, were frequency-matched to cases on age, sex, and race. This analysis was based on 989 white and 351 African-American cases and 1,114 white and 264 African-American controls. Analyses were performed using unconditional logistic regression, adjusting for age, sex, race, education, and fruit and vegetable consumption. RESULTS: The association between SCCHN and ever tobacco use among African-Americans (odds ratio (OR), 9.68; 95 % confidence interval (CI), 4.70, 19.9) was much greater than that observed in whites (OR, 1.94; 95 % CI, 1.51, 2.50). Smaller differences were observed when examining ever alcohol use (African-Americans: OR, 3.71; CI, 1.65, 8.30, and Whites: OR, 1.31: CI 0.96, 1.78). African-Americans consistently had greater effect measure estimates when examining common levels of duration and intensity metrics of tobacco and alcohol use, both independently and jointly. No racial differences in the effects of environmental (passive) tobacco smoke were observed. CONCLUSIONS: These findings suggest racial differences in SCCHN are not solely explained by differences in consumption patterns, and tobacco and alcohol may have greater impact in African-Americans.
PURPOSE:Tobacco and alcohol use are well-known risk factors for squamous cell carcinoma of the head and neck (SCCHN), but there has been little examination of disparities in SCCHN and racial patterns of tobacco and alcohol use, especially for African-Americans. The Carolina Head and Neck Cancer Study, a population-based case-control study, was utilized to determine whether relationships between tobacco and alcohol use and SCCHN differed by race. METHODS: Using a rapid case ascertainment system, cases were recruited from 46 contiguous counties in North Carolina from 2002 to 2006. Controls, selected from motor vehicle records, were frequency-matched to cases on age, sex, and race. This analysis was based on 989 white and 351 African-American cases and 1,114 white and 264 African-American controls. Analyses were performed using unconditional logistic regression, adjusting for age, sex, race, education, and fruit and vegetable consumption. RESULTS: The association between SCCHN and ever tobacco use among African-Americans (odds ratio (OR), 9.68; 95 % confidence interval (CI), 4.70, 19.9) was much greater than that observed in whites (OR, 1.94; 95 % CI, 1.51, 2.50). Smaller differences were observed when examining ever alcohol use (African-Americans: OR, 3.71; CI, 1.65, 8.30, and Whites: OR, 1.31: CI 0.96, 1.78). African-Americans consistently had greater effect measure estimates when examining common levels of duration and intensity metrics of tobacco and alcohol use, both independently and jointly. No racial differences in the effects of environmental (passive) tobacco smoke were observed. CONCLUSIONS: These findings suggest racial differences in SCCHN are not solely explained by differences in consumption patterns, and tobacco and alcohol may have greater impact in African-Americans.
Authors: Mark P Purdue; Mia Hashibe; Julien Berthiller; Carlo La Vecchia; Luigino Dal Maso; Rolando Herrero; Silvia Franceschi; Xavier Castellsague; Qingyi Wei; Erich M Sturgis; Hal Morgenstern; Zuo-Feng Zhang; Fabio Levi; Renato Talamini; Elaine Smith; Joshua Muscat; Philip Lazarus; Stephen M Schwartz; Chu Chen; Jose Eluf Neto; Victor Wünsch-Filho; David Zaridze; Sergio Koifman; Maria Paula Curado; Simone Benhamou; Elena Matos; Neonilia Szeszenia-Dabrowska; Andrew F Olshan; Juan Lence; Ana Menezes; Alexander W Daudt; Ioan Nicolae Mates; Agnieszka Pilarska; Eleonora Fabianova; Peter Rudnai; Debbie Winn; Gilles Ferro; Paul Brennan; Paolo Boffetta; Richard B Hayes Journal: Am J Epidemiol Date: 2008-12-08 Impact factor: 4.897
Authors: A Blythe Ryerson; Edward S Peters; Steven S Coughlin; Vivien W Chen; Maura L Gillison; Marsha E Reichman; Xiaocheng Wu; Anil K Chaturvedi; Kelly Kawaoka Journal: Cancer Date: 2008-11-15 Impact factor: 6.860
Authors: Yuan-Chin Amy Lee; Paolo Boffetta; Erich M Sturgis; Qingyi Wei; Zuo-Feng Zhang; Joshua Muscat; Philip Lazarus; Elena Matos; Richard B Hayes; Deborah M Winn; David Zaridze; Victor Wünsch-Filho; Jose Eluf-Neto; Sergio Koifman; Dana Mates; Maria Paula Curado; Ana Menezes; Leticia Fernandez; Alexander W Daudt; Neonila Szeszenia-Dabrowska; Eleonora Fabianova; Peter Rudnai; Gilles Ferro; Julien Berthiller; Paul Brennan; Mia Hashibe Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-08 Impact factor: 4.254
Authors: W Jarrard Goodwin; Giovana R Thomas; Dorothy F Parker; Debbie Joseph; Silvina Levis; Elizabeth Franzmann; Charles Anello; Jennifer J Hu Journal: Head Neck Date: 2008-03 Impact factor: 3.147
Authors: Katie M Applebaum; C Sloane Furniss; Ariana Zeka; Marshall R Posner; Judith F Smith; Janine Bryan; Ellen A Eisen; Edward S Peters; Michael D McClean; Karl T Kelsey Journal: J Natl Cancer Inst Date: 2007-11-27 Impact factor: 13.506
Authors: Leonor Varela-Lema; Emanuela Taioli; Alberto Ruano-Ravina; Juan M Barros-Dios; Devasena Anantharaman; Simone Benhamou; Stefania Boccia; Rajani A Bhisey; Gabriella Cadoni; Ettore Capoluongo; Chien-Jen Chen; William Foulkes; Eny Maria Goloni-Bertollo; Ana Hatagima; Richard B Hayes; Takahiko Katoh; Sergio Koifman; Phillip Lazarus; Johannes J Manni; Manoj Mahimkar; Shunji Morita; Jong Park; Kwang-Kyun Park; Erika Cristina Pavarino Bertelli; Enilze Maria de Souza Fonseca Ribeiro; Bidyut Roy; Margaret R Spitz; Richard C Strange; Qingyi Wei; Camille C Ragin Journal: Genet Med Date: 2008-06 Impact factor: 8.822
Authors: Kathleen M McClain; Patrick T Bradshaw; Nikhil K Khankari; Marilie D Gammon; Andrew F Olshan Journal: Eur J Cancer Prev Date: 2019-03 Impact factor: 2.497
Authors: Annah B Wyss; Mia Hashibe; Yuan-Chin Amy Lee; Shu-Chun Chuang; Joshua Muscat; Chu Chen; Stephen M Schwartz; Elaine Smith; Zuo-Feng Zhang; Hal Morgenstern; Qingyi Wei; Guojun Li; Karl T Kelsey; Michael McClean; Deborah M Winn; Stimson Schantz; Guo-Pei Yu; Maura L Gillison; Jose P Zevallos; Paolo Boffetta; Andrew F Olshan Journal: Am J Epidemiol Date: 2016-11-15 Impact factor: 4.897
Authors: Eboneé N Butler; Chiu-Kit Tse; Mary Elizabeth Bell; Kathleen Conway; Andrew F Olshan; Melissa A Troester Journal: Cancer Causes Control Date: 2016-05-06 Impact factor: 2.506
Authors: Annah B Wyss; Mark C Weissler; Christy L Avery; Amy H Herring; Jeannette T Bensen; Jill S Barnholtz-Sloan; William K Funkhouser; Andrew F Olshan Journal: Cancer Causes Control Date: 2014-02-02 Impact factor: 2.506
Authors: Dan P Zandberg; Sandy Liu; Olga Goloubeva; Robert Ord; Scott E Strome; Mohan Suntharalingam; Rodney Taylor; Robert E Morales; Jeffrey S Wolf; Ann Zimrin; Joshua E Lubek; Lisa M Schumaker; Kevin J Cullen Journal: Head Neck Date: 2015-06-30 Impact factor: 3.147
Authors: Jessica L Petrick; Mia M Gaudet; Mark C Weissler; William K Funkhouser; Andrew F Olshan Journal: Ann Epidemiol Date: 2013-11-16 Impact factor: 3.797
Authors: Caryn E Peterson; Shaveta Khosla; Lucy F Chen; Charlotte E Joslin; Faith G Davis; Marian L Fitzgibbon; Sally Freels; Kent Hoskins Journal: J Cancer Res Clin Oncol Date: 2016-06-01 Impact factor: 4.553