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Literature DB >> 22673640

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy.

Zijuan Zhang¹, Nicholas Kwiatkowski, Hong Zeng, Sang Min Lim, Nathanael S Gray, Wei Zhang, Priscilla L Yang.

Abstract

As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2012 PMID： 22673640 PMCID： PMC3616611 DOI： 10.1039/c2mb25099c

Source DB: PubMed Journal: Mol Biosyst ISSN： 1742-2051

28 in total

1. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.

Authors: David V Hansen; Alexander V Loktev; Kenneth H Ban; Peter K Jackson
Journal: Mol Biol Cell Date: 2004-10-06 Impact factor: 4.138

2. Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores.

Authors: Song-Tao Liu; Gordon K T Chan; James C Hittle; Gregory Fujii; Emma Lees; Tim J Yen
Journal: Mol Biol Cell Date: 2003-04 Impact factor: 4.138

3. Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

Authors: A Abrieu; L Magnaghi-Jaulin; J A Kahana; M Peter; A Castro; S Vigneron; T Lorca; D W Cleveland; J C Labbé
Journal: Cell Date: 2001-07-13 Impact factor: 41.582

4. Dimers of dipyrrometheneboron difluoride (BODIPY) with light spectroscopic applications in chemistry and biology.

Authors: Fredrik Bergström; Ilya Mikhalyov; Peter Hägglöf; Rüdiger Wortmann; Tor Ny; Lennart B A Johansson
Journal: J Am Chem Soc Date: 2002-01-16 Impact factor: 15.419

5. The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.

Authors: Naoki Oshimori; Miho Ohsugi; Tadashi Yamamoto
Journal: Nat Cell Biol Date: 2006-09-17 Impact factor: 28.824

6. The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

Authors: Péter Lénárt; Mark Petronczki; Martin Steegmaier; Barbara Di Fiore; Jesse J Lipp; Matthias Hoffmann; Wolfgang J Rettig; Norbert Kraut; Jan-Michael Peters
Journal: Curr Biol Date: 2007-02-08 Impact factor: 10.834

7. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.

Authors: Andrew E H Elia; Lewis C Cantley; Michael B Yaffe
Journal: Science Date: 2003-02-21 Impact factor: 47.728

8. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.

Authors: Yakir Moshe; Jérôme Boulaire; Michele Pagano; Avram Hershko
Journal: Proc Natl Acad Sci U S A Date: 2004-05-17 Impact factor: 11.205

Review 9. From Plk1 to Plk5: functional evolution of polo-like kinases.

Authors: Guillermo de Cárcer; Gerard Manning; Marcos Malumbres
Journal: Cell Cycle Date: 2011-07-15 Impact factor: 4.534

10. Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.

Authors: Rüdiger Neef; Christian Preisinger; Josephine Sutcliffe; Robert Kopajtich; Erich A Nigg; Thomas U Mayer; Francis A Barr
Journal: J Cell Biol Date: 2003-08-25 Impact factor: 10.539

10 in total

1. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.

Authors: Keiko Rausch; Brent A Hackett; Nathan L Weinbren; Sophia M Reeder; Yoel Sadovsky; Christopher A Hunter; David C Schultz; Carolyn B Coyne; Sara Cherry
Journal: Cell Rep Date: 2017-01-17 Impact factor: 9.423

2. BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.

Authors: Alex M Ayoub; Laura M L Hawk; Ryan J Herzig; Jiewei Jiang; Andrea J Wisniewski; Clifford T Gee; Peiliang Zhao; Jin-Yi Zhu; Norbert Berndt; Nana K Offei-Addo; Thomas G Scott; Jun Qi; James E Bradner; Timothy R Ward; Ernst Schönbrunn; Gunda I Georg; William C K Pomerantz
Journal: J Med Chem Date: 2017-06-07 Impact factor: 7.446

3. Paramagnetic relaxation enhancement for protein-observed ¹⁹F NMR as an enabling approach for efficient fragment screening.

Authors: Laura M L Hawk; Clifford T Gee; Andrew K Urick; Haitao Hu; William C K Pomerantz
Journal: RSC Adv Date: 2016-09-29 Impact factor: 3.361

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy.

1. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.

2. Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores.

3. Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

4. Dimers of dipyrrometheneboron difluoride (BODIPY) with light spectroscopic applications in chemistry and biology.

5. The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.

6. The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1.

7. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.

8. Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.

Review 9. From Plk1 to Plk5: functional evolution of polo-like kinases.

10. Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.

1. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.

2. BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.

3. Paramagnetic relaxation enhancement for protein-observed ¹⁹F NMR as an enabling approach for efficient fragment screening.

4. Protein-Observed Fluorine NMR Is a Complementary Ligand Discovery Method to ¹H CPMG Ligand-Observed NMR.

5. Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules.

6. A new genre of fluorescence recovery assay to evaluate polo-like kinase 1 ATP-competitive inhibitors.

7. Fluorescent visualization of Src by using dasatinib-BODIPY.

8. Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells.

Review 9. Fluorescent kinase inhibitors as probes in cancer.

10. Kinase-templated abiotic reaction.