PURPOSE: In this work, the treatment tolerance of elderly patients (≥70 years) undergoing intensity-modulated radiotherapy (IMRT) and image-guided radiotherapy (IGRT) and chemotherapy for locally advanced head and neck cancer was assessed. PATIENTS AND METHODS: A retrospective review of 112 patients undergoing concurrent chemoradiation for locally advanced head and neck cancer was performed. Treatment toxicity, protocol violations, long-term complications, and survival were compared between 85 younger patients (< 70 years) and 27 older patients (≥ 70 years). RESULTS: Grade 3-4 treatment toxicity was observed in 88.2% and 88.8% for younger and older patients, respectively. Mean weight loss and treatment break were 5.9 and 3.9 kg (p = 0.03) and 7.3 and 7.8 days (p = 0.8) for younger and older patients, respectively. Seven patients (8.2%) did not complete treatment in the younger group compared to 1 patient (3.7%) in the older group (p = 0.6). No significant differences in protocol violations and survival were found between the two groups. CONCLUSION: Compared to younger patients, elderly patients with locally advanced head and neck cancer tolerated chemoradiation with IMRT and IGRT well, and should not be denied curative treatment based solely on age.
PURPOSE: In this work, the treatment tolerance of elderly patients (≥70 years) undergoing intensity-modulated radiotherapy (IMRT) and image-guided radiotherapy (IGRT) and chemotherapy for locally advanced head and neck cancer was assessed. PATIENTS AND METHODS: A retrospective review of 112 patients undergoing concurrent chemoradiation for locally advanced head and neck cancer was performed. Treatment toxicity, protocol violations, long-term complications, and survival were compared between 85 younger patients (< 70 years) and 27 older patients (≥ 70 years). RESULTS: Grade 3-4 treatment toxicity was observed in 88.2% and 88.8% for younger and older patients, respectively. Mean weight loss and treatment break were 5.9 and 3.9 kg (p = 0.03) and 7.3 and 7.8 days (p = 0.8) for younger and older patients, respectively. Seven patients (8.2%) did not complete treatment in the younger group compared to 1 patient (3.7%) in the older group (p = 0.6). No significant differences in protocol violations and survival were found between the two groups. CONCLUSION: Compared to younger patients, elderly patients with locally advanced head and neck cancer tolerated chemoradiation with IMRT and IGRT well, and should not be denied curative treatment based solely on age.
Authors: G Calais; M Alfonsi; E Bardet; C Sire; T Germain; P Bergerot; B Rhein; J Tortochaux; P Oudinot; P Bertrand Journal: J Natl Cancer Inst Date: 1999-12-15 Impact factor: 13.506
Authors: Daniel J Givens; Lucy Hynds Karnell; Anjali K Gupta; Gerald H Clamon; Nitin A Pagedar; Kristi E Chang; Douglas J Van Daele; Gerry F Funk Journal: Arch Otolaryngol Head Neck Surg Date: 2009-12
Authors: Jacques Bernier; Jay S Cooper; T F Pajak; M van Glabbeke; J Bourhis; Arlene Forastiere; Esat Mahmut Ozsahin; John R Jacobs; J Jassem; Kie-Kian Ang; J L Lefèbvre Journal: Head Neck Date: 2005-10 Impact factor: 3.147
Authors: Nathan A Berger; Panos Savvides; Siran M Koroukian; Eva F Kahana; Gary T Deimling; Julia H Rose; Karen F Bowman; Robert H Miller Journal: Trans Am Clin Climatol Assoc Date: 2006
Authors: N P Nguyen; C C Moltz; C Frank; P Vos; H J Smith; U Karlsson; S Dutta; F A Midyett; J Barloon; S Sallah Journal: Ann Oncol Date: 2004-03 Impact factor: 32.976
Authors: Sheela Hanasoge; Kelly R Magliocca; Jeffrey M Switchenko; Nabil F Saba; J Trad Wadsworth; Mark W El-Deiry; Dong M Shin; Fadlo Khuri; Jonathan J Beitler; Kristin A Higgins Journal: Head Neck Date: 2015-07-30 Impact factor: 3.147
Authors: Stefan Huttenlocher; Nina D Seibold; Maximilian P Gebhard; Frank Noack; Christoph Thorns; Katrin Hasselbacher; Barbara Wollenberg; Steven E Schild; Dirk Rades Journal: Strahlenther Onkol Date: 2014-06-14 Impact factor: 3.621
Authors: M Di Genesio Pagliuca; C Perotti; G Apicella; A Galla; M Guffi; M Paolini; L Donis; V Amisano; S Torrente; I Manfredda; M Krengli Journal: Clin Transl Oncol Date: 2015-09-14 Impact factor: 3.405
Authors: Shrujal S Baxi; Caitriona O'Neill; Eric J Sherman; Coral L Atoria; Nancy Y Lee; David G Pfister; Elena B Elkin Journal: Head Neck Date: 2015-06-26 Impact factor: 3.147
Authors: D Rades; N D Seibold; A Hoffmann; M P Gebhard; F Noack; C Thorns; S E Schild Journal: Strahlenther Onkol Date: 2013-07-17 Impact factor: 3.621