Literature DB >> 22658510

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins.

Michelle A Dunstone1, Rodney K Tweten.   

Abstract

The bacterial cholesterol dependent cytolysins (CDCs) and membrane attack complex/perforin-like proteins (MACPF) represent two major branches of a large, exceptionally diverged superfamily. Most characterized CDC/MACPF proteins form large pores that function in immunity, venoms, and pathogenesis. Extensive structural, biochemical and biophysical studies have started to address some of the questions surrounding how the soluble, monomeric form of these remarkable molecules recognize diverse targets and assemble into oligomeric membrane embedded pores. This review explores mechanistic similarities and differences in how CDCs and MACPF proteins form pores.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22658510      PMCID： PMC3383384          DOI： 10.1016/j.sbi.2012.04.008

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  63 in total

1.  Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin.

Authors:  Rajesh Ramachandran; Alejandro P Heuck; Rodney K Tweten; Arthur E Johnson
Journal:  Nat Struct Biol       Date:  2002-11

2.  Cloning, expression, and pore-forming properties of mature and precursor forms of pleurotolysin, a sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus.

Authors:  Nobuki Sakurai; Jun Kaneko; Yoshiyuki Kamio; Toshio Tomita
Journal:  Biochim Biophys Acta       Date:  2004-07-13

3.  Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex.

Authors:  Toshio Tomita; Kayoko Noguchi; Hitomi Mimuro; Fumio Ukaji; Kiyoshi Ito; Noriko Sugawara-Tomita; Yohichi Hashimoto
Journal:  J Biol Chem       Date:  2004-04-14       Impact factor: 5.157

4.  The structural events associated with the attachment of complement components to cell membranes in reactive lysis.

Authors:  R R Dourmashkin
Journal:  Immunology       Date:  1978-08       Impact factor: 7.397

5.  Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate.

Authors:  E M Hotze; E M Wilson-Kubalek; J Rossjohn; M W Parker; A E Johnson; R K Tweten
Journal:  J Biol Chem       Date:  2000-12-01       Impact factor: 5.157

6.  Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene.

Authors:  M M Awad; D M Ellemor; R L Boyd; J J Emmins; J I Rood
Journal:  Infect Immun       Date:  2001-12       Impact factor: 3.441

7.  Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment.

Authors:  Rajesh Ramachandran; Rodney K Tweten; Arthur E Johnson
Journal:  Nat Struct Mol Biol       Date:  2004-07-04       Impact factor: 15.369

8.  Novel proteinaceous toxins from the nematocyst venom of the Okinawan sea anemone Phyllodiscus semoni Kwietniewski.

Authors:  Hiroshi Nagai; Naomasa Oshiro; Kyoko Takuwa-Kuroda; Setsuko Iwanaga; Masatoshi Nozaki; Terumi Nakajima
Journal:  Biochem Biophys Res Commun       Date:  2002-06-21       Impact factor: 3.575

9.  Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane.

Authors:  Daniel M Czajkowsky; Eileen M Hotze; Zhifeng Shao; Rodney K Tweten
Journal:  EMBO J       Date:  2004-08-05       Impact factor: 11.598

10.  Structural basis of pore formation by the bacterial toxin pneumolysin.

Authors:  Sarah J Tilley; Elena V Orlova; Robert J C Gilbert; Peter W Andrew; Helen R Saibil
Journal:  Cell       Date:  2005-04-22       Impact factor: 41.582
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  44 in total

1.  Type 3 Secretion Translocators Spontaneously Assemble a Hexadecameric Transmembrane Complex.

Authors:  Fabian B Romano; Yuzhou Tang; Kyle C Rossi; Kathryn R Monopoli; Jennifer L Ross; Alejandro P Heuck
Journal:  J Biol Chem       Date:  2016-01-19       Impact factor: 5.157

2.  Perforin Promotes Amyloid Beta Internalisation in Neurons.

Authors:  Erica Lana; Mahbod Khanbolouki; Charline Degavre; Eva-Britt Samuelsson; Elisabet Åkesson; Bengt Winblad; Evren Alici; Christina Unger Lithner; Homira Behbahani
Journal:  Mol Neurobiol       Date:  2016-01-16       Impact factor: 5.590

3.  Sequential steps in the assembly of the multimeric outer membrane secretin PulD.

Authors:  Gerard H M Huysmans; Ingrid Guilvout; Anthony P Pugsley
Journal:  J Biol Chem       Date:  2013-09-09       Impact factor: 5.157

Review 4.  Getting across the cell membrane: an overview for small molecules, peptides, and proteins.

Authors:  Nicole J Yang; Marlon J Hinner
Journal:  Methods Mol Biol       Date:  2015

5.  An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin.

Authors:  Kristin R Wade; Eileen M Hotze; Michael J Kuiper; Craig J Morton; Michael W Parker; Rodney K Tweten
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-02       Impact factor: 11.205

Review 6.  Building membrane nanopores.

Authors:  Stefan Howorka
Journal:  Nat Nanotechnol       Date:  2017-07-06       Impact factor: 39.213

7.  A monodisperse transmembrane α-helical peptide barrel.

Authors:  Kozhinjampara R Mahendran; Ai Niitsu; Lingbing Kong; Andrew R Thomson; Richard B Sessions; Derek N Woolfson; Hagan Bayley
Journal:  Nat Chem       Date:  2016-11-14       Impact factor: 24.427

Review 8.  Effects of MACPF/CDC proteins on lipid membranes.

Authors:  Robert J C Gilbert; Miha Mikelj; Mauro Dalla Serra; Christopher J Froelich; Gregor Anderluh
Journal:  Cell Mol Life Sci       Date:  2012-09-15       Impact factor: 9.261

9.  Functional dissection of Toxoplasma gondii perforin-like protein 1 reveals a dual domain mode of membrane binding for cytolysis and parasite egress.

Authors:  Marijo S Roiko; Vern B Carruthers
Journal:  J Biol Chem       Date:  2013-02-02       Impact factor: 5.157

10.  The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection.

Authors:  Chen Chen; Brittney N Nguyen; Gabriel Mitchell; Shally R Margolis; Darren Ma; Daniel A Portnoy
Journal:  Cell Host Microbe       Date:  2018-06-13       Impact factor: 21.023
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