Literature DB >> 22654996

Algorithms for optimization of the transport system in living and artificial cells.

A V Melkikh1, M I Sutormina.   

Abstract

An optimization of the transport system in a cell has been considered from the viewpoint of the operations research. Algorithms for an optimization of the transport system of a cell in terms of both the efficiency and a weak sensitivity of a cell to environmental changes have been proposed. The switching of various systems of transport is considered as the mechanism of weak sensitivity of a cell to changes in environment. The use of the algorithms for an optimization of a cardiac cell has been considered by way of example. We received theoretically for a cell of a cardiac muscle that at the increase of potassium concentration in the environment switching of transport systems for this ion takes place. This conclusion qualitatively coincides with experiments. The problem of synthesizing an optimal system in an artificial cell has been stated.

Entities:  

Keywords:  Efficiency; Game theory; Robustness; Synthetic biology; Systems biology; Transport of ions

Year:  2011        PMID: 22654996      PMCID: PMC3159698          DOI: 10.1007/s11693-011-9083-6

Source DB:  PubMed          Journal:  Syst Synth Biol        ISSN: 1872-5325


  23 in total

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Authors:  A Ben-Dor; R Shamir; Z Yakhini
Journal:  J Comput Biol       Date:  1999 Fall-Winter       Impact factor: 1.479

2.  Models of active transport of ions in biomembranes of various types of cells.

Authors:  Alexey V Melkikh; Vladimir D Seleznev
Journal:  J Theor Biol       Date:  2005-01-25       Impact factor: 2.691

3.  Requirements on models and models of active transport of ions in biomembranes.

Authors:  A V Melkikh; V D Seleznev
Journal:  Bull Math Biol       Date:  2006-03-30       Impact factor: 1.758

Review 4.  Magnesium transporters: properties, regulation and structure.

Authors:  Michael E Maguire
Journal:  Front Biosci       Date:  2006-09-01

5.  Early stages of the evolution of life: a cybernetic approach.

Authors:  Alexey V Melkikh; Vladimir D Seleznev
Journal:  Orig Life Evol Biosph       Date:  2008-06-03       Impact factor: 1.950

Review 6.  Network thermodynamics: dynamic modelling of biophysical systems.

Authors:  G F Oster; A S Perelson; A Katchalsky
Journal:  Q Rev Biophys       Date:  1973-02       Impact factor: 5.318

Review 7.  The role of cellular hydration in the regulation of cell function.

Authors:  D Häussinger
Journal:  Biochem J       Date:  1996-02-01       Impact factor: 3.857

8.  Na+/H+ exchange and osmotic shrinkage in isolated trout hepatocytes

Authors: 
Journal:  J Exp Biol       Date:  1997       Impact factor: 3.312

9.  Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon.

Authors:  J A Payne; J C Xu; M Haas; C Y Lytle; D Ward; B Forbush
Journal:  J Biol Chem       Date:  1995-07-28       Impact factor: 5.157

10.  Towards a theory of biological robustness.

Authors:  Hiroaki Kitano
Journal:  Mol Syst Biol       Date:  2007-09-18       Impact factor: 11.429

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