| Literature DB >> 22652221 |
Y Xu1, Lingling Qian, Guijuan Zong, K Ma, X Zhu, H Zhang, N Li, Q Yang, H Bai, J Ben, X Li, Y Xu1, Q Chen.
Abstract
Class A scavenger receptor (SR-A) is primarily expressed in microglia/macrophages and plays an important role in immune responses. However, whether SR-A can influence microglia/macrophage polarization in cerebral ischemic injury is not known. To this end we monitored the phenotypic alteration of microglia/macrophages in an animal model of cerebral ischemia injury. SR-A was up-regulated in mouse brains 24h after permanent occlusion of middle cerebral artery (MCAO). SR-A-deficient mice displayed reduced infarct size and improved neurological function compared with wild-type mice littermate controls. Furthermore, a decrease in inflammatory F4/80(+)CD11b(+)CD45(high)CD11c(+) microglia/macrophages and attenuated nuclear factor-kappaB (NF-κB) activation was found in ischemic brains in the SR-A null mice. This was accompanied by alleviation of classically activated M1 macrophage markers and preservation of alternatively activated M2 macrophage markers. These data suggest that SR-A contributes to cerebral ischemic injury by pivoting the phenotype of microglia/macrophages to a skewed M1 polarization.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22652221 DOI： 10.1016/j.neuroscience.2012.05.036
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590