Literature DB >> 22649098

Signal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signaling.

Henrik G Dohlman1, Janice C Jones.   

Abstract

Heterotrimeric guanine nucleotide-binding proteins (G proteins) are positioned at the top of many signal transduction pathways. The G protein α subunit is composed of two domains, one that resembles Ras and another that is composed entirely of α helices. Historically most attention has focused on the Ras-like domain, but emerging evidence reveals that the helical domain is an active participant in G protein signaling.

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Year:  2012        PMID： 22649098      PMCID： PMC3557789          DOI： 10.1126/scisignal.2003013

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   8.192


  46 in total

1.  Receptor-mediated activation of heterotrimeric G-proteins in living cells.

Authors:  C Janetopoulos; T Jin; P Devreotes
Journal:  Science       Date:  2001-03-23       Impact factor: 47.728

2.  Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins.

Authors:  Janice C Jones; Alan M Jones; Brenda R S Temple; Henrik G Dohlman
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-23       Impact factor: 11.205

Review 3.  Understanding protein non-folding.

Authors:  Vladimir N Uversky; A Keith Dunker
Journal:  Biochim Biophys Acta       Date:  2010-02-01

4.  Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.

Authors:  Céline Galés; Joost J J Van Durm; Stéphane Schaak; Stéphanie Pontier; Yann Percherancier; Martin Audet; Hervé Paris; Michel Bouvier
Journal:  Nat Struct Mol Biol       Date:  2006-08-13       Impact factor: 15.369

Review 5.  Heterotrimeric G protein activation by G-protein-coupled receptors.

Authors:  William M Oldham; Heidi E Hamm
Journal:  Nat Rev Mol Cell Biol       Date:  2008-01       Impact factor: 94.444

6.  Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.

Authors:  C V Carman; J L Parent; P W Day; A N Pronin; P M Sternweis; P B Wedegaertner; A G Gilman; J L Benovic; T Kozasa
Journal:  J Biol Chem       Date:  1999-11-26       Impact factor: 5.157

7.  Tyrosine phosphorylation of the alpha subunit of transducin and its association with Src in photoreceptor rod outer segments.

Authors:  M W Bell; N Desai; X X Guo; A J Ghalayini
Journal:  J Neurochem       Date:  2000-11       Impact factor: 5.372

8.  Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

Authors:  Meera Soundararajan; Francis S Willard; Adam J Kimple; Andrew P Turnbull; Linda J Ball; Guillaume A Schoch; Carina Gileadi; Oleg Y Fedorov; Elizabeth F Dowler; Victoria A Higman; Stephanie Q Hutsell; Michael Sundström; Declan A Doyle; David P Siderovski
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-23       Impact factor: 11.205

9.  Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation.

Authors:  Kevin C Slep; Michele A Kercher; Thomas Wieland; Ching-Kang Chen; Melvin I Simon; Paul B Sigler
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-23       Impact factor: 11.205

10.  Tight regulation of unstructured proteins: from transcript synthesis to protein degradation.

Authors:  Jörg Gsponer; Matthias E Futschik; Sarah A Teichmann; M Madan Babu
Journal:  Science       Date:  2008-11-28       Impact factor: 47.728
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  13 in total

1.  Guanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast.

Authors:  Gauri Dixit; Rachael Baker; Carly M Sacks; Matthew P Torres; Henrik G Dohlman
Journal:  J Biol Chem       Date:  2014-04-10       Impact factor: 5.157

Review 2.  Protein Regulation in Signal Transduction.

Authors:  Michael J Lee; Michael B Yaffe
Journal:  Cold Spring Harb Perspect Biol       Date:  2016-06-01       Impact factor: 10.005

3.  SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Authors:  Ron O Dror; Thomas J Mildorf; Daniel Hilger; Aashish Manglik; David W Borhani; Daniel H Arlow; Ansgar Philippsen; Nicolas Villanueva; Zhongyu Yang; Michael T Lerch; Wayne L Hubbell; Brian K Kobilka; Roger K Sunahara; David E Shaw
Journal:  Science       Date:  2015-06-19       Impact factor: 47.728

Review 4.  The Conformational Dynamics of Heterotrimeric G Proteins During GPCR-Mediated Activation.

Authors:  Donghoon Ahn; Ka Young Chung
Journal:  Subcell Biochem       Date:  2022

5.  Substrate specificity of Pasteurella multocida toxin for α subunits of heterotrimeric G proteins.

Authors:  Joachim H C Orth; Ines Fester; Peter Siegert; Markus Weise; Ulrike Lanner; Shigeki Kamitani; Taro Tachibana; Brenda A Wilson; Andreas Schlosser; Yasuhiko Horiguchi; Klaus Aktories
Journal:  FASEB J       Date:  2012-11-12       Impact factor: 5.191

Review 6.  Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.

Authors:  Stephen R Sprang
Journal:  Biopolymers       Date:  2016-08       Impact factor: 2.505

7.  Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor.

Authors:  Minfei Su; Lan Zhu; Yixiao Zhang; Navid Paknejad; Raja Dey; Jianyun Huang; Ming-Yue Lee; Dewight Williams; Kelsey D Jordan; Edward T Eng; Oliver P Ernst; Joel R Meyerson; Richard K Hite; Thomas Walz; Wei Liu; Xin-Yun Huang
Journal:  Mol Cell       Date:  2020-08-19       Impact factor: 17.970

8.  An intact helical domain is required for Gα14 to stimulate phospholipase Cβ.

Authors:  Dawna H T Kwan; Ka M Wong; Anthony S L Chan; Lisa Y Yung; Yung H Wong
Journal:  BMC Struct Biol       Date:  2015-09-16

9.  Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model.

Authors:  Min Hyeok Kim; Young Jin Kim; Hee Ryung Kim; Tae-Joon Jeon; Jae Boong Choi; Ka Young Chung; Moon Ki Kim
Journal:  PLoS One       Date:  2016-08-02       Impact factor: 3.240

10.  Nullspace Sampling with Holonomic Constraints Reveals Molecular Mechanisms of Protein Gαs.

Authors:  Dimitar V Pachov; Henry van den Bedem
Journal:  PLoS Comput Biol       Date:  2015-07-28       Impact factor: 4.475
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