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Literature DB >> 2264839

Glycoprotein II from adrenal chromaffin granules is also present in kidney lysosomes.

R Weiler¹, H J Steiner, K W Schmid, D Obendorf, H Winkler.

Abstract

Glycoprotein II (GP II) is a protein found in the membranes of chromaffin granules from adrenal medulla. Immunoblotting (one- and two-dimensional) revealed that this antigen is also present in liver and in kidney. Subcellular fractionation of the latter organ indicated that GP II was present in lysosomes. This was confirmed by immunoelectron microscopy. The antiserum against GP II immunolabelled the membranes of organelles which could be identified as lysosomes by the labelling of their contents with an antiserum against cathepsin D. Thus GP II is an antigen common to secretory vesicles and lysosomes.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1990 PMID： 2264839 PMCID： PMC1149660 DOI： 10.1042/bj2720087

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

27 in total

6. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.

Authors: W N Burnette
Journal: Anal Biochem Date: 1981-04 Impact factor: 3.365

7. Isolation and purification of acid phosphatase-containing autofluorescent granules from homogenates of rat kidney cortex.

Authors: A B Maunsbach
Journal: J Ultrastruct Res Date: 1966-09

Review 3. Membrane composition of adrenergic large and small dense cored vesicles and of synaptic vesicles: consequences for their biogenesis.

Authors: H Winkler
Journal: Neurochem Res Date: 1997-08 Impact factor: 3.996

Review 4. The adrenal chromaffin granule: a model for large dense core vesicles of endocrine and nervous tissue.

Authors: H Winkler
Journal: J Anat Date: 1993-10 Impact factor: 2.610

4 in total

Glycoprotein II from adrenal chromaffin granules is also present in kidney lysosomes.

1. Protein measurement with the Folin phenol reagent.

2. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

3. Cytochrome b561 is identical with chromomembrin B, a major polypeptide of chromaffin granule membranes.

4. Characterization and topography of the glycoproteins of adrenal chromaffin granules.

Review 5. The composition of adrenal chromaffin granules: an assessment of controversial results.

6. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.

7. Isolation and purification of acid phosphatase-containing autofluorescent granules from homogenates of rat kidney cortex.

8. The localization of lysosomal enzymes in chromaffin tissue.

9. A simple method for the isolation of adrenal chromaffin granules on a large scale.

10. Membrane proteins of chromaffin granules, dopamine -hydroxylase, a major constituent.

1. Undegraded chromogranin A is present in serum and enters the endocytotic lysosomal pathway in kidney.

Review 2. Sorting and storage during secretory granule biogenesis: looking backward and looking forward.

Review 3. Membrane composition of adrenergic large and small dense cored vesicles and of synaptic vesicles: consequences for their biogenesis.

Review 4. The adrenal chromaffin granule: a model for large dense core vesicles of endocrine and nervous tissue.