M A R Feliciano1, W R R Vicente, M A M Silva. 1. Department of Animal Reproduction, College of Agricultural and Veterinary Sciences, Sao Paulo State University, Sao Paulo, Brazil.
Abstract
OBJECTIVES: The aim of this study was to evaluate the sensitivity of conventional and Doppler ultrasound for differentiation of benign and malignant mammary tumours in female dogs. METHODS: Mammary tumours were evaluated from 60 animals and divided into two distinct groups, group 1 (benign tumours) and group 2 (malignant tumours). The tumours were assessed by conventional ultrasound, Doppler ultrasound mode, histopathology and immunohistochemical detection of vascular endothelial growth factor. RESULTS: Conventional ultrasound examination was found to be ineffective in separating tumours into the two experimental groups. Similarly, using colour-flow Doppler ultrasound, no correlation was found between the presence of vascularisation and its characteristics between the two groups. Triplex Doppler ultrasound yielded average maximum velocities of 28·71 cm/s for malignant and 19·91 cm/s for benign tumours, which were significantly different (P=0·01). For vascular endothelial growth factor, an average score of 2·22 was found for group 2 and 1·66 for group 1 (P=0·03). Positive correlations were found between vascular endothelial growth factor and presence of vascularisation (P=0·04 and r=0·3658) and between vascular endothelial growth factor and maximum velocity (P=0·03 and r=0·3913). CLINICAL SIGNIFICANCE: Doppler evaluation may be used to predict malignancy of mammary tumours in bitches.
OBJECTIVES: The aim of this study was to evaluate the sensitivity of conventional and Doppler ultrasound for differentiation of benign and malignant mammary tumours in female dogs. METHODS: Mammary tumours were evaluated from 60 animals and divided into two distinct groups, group 1 (benign tumours) and group 2 (malignant tumours). The tumours were assessed by conventional ultrasound, Doppler ultrasound mode, histopathology and immunohistochemical detection of vascular endothelial growth factor. RESULTS: Conventional ultrasound examination was found to be ineffective in separating tumours into the two experimental groups. Similarly, using colour-flow Doppler ultrasound, no correlation was found between the presence of vascularisation and its characteristics between the two groups. Triplex Doppler ultrasound yielded average maximum velocities of 28·71 cm/s for malignant and 19·91 cm/s for benign tumours, which were significantly different (P=0·01). For vascular endothelial growth factor, an average score of 2·22 was found for group 2 and 1·66 for group 1 (P=0·03). Positive correlations were found between vascular endothelial growth factor and presence of vascularisation (P=0·04 and r=0·3658) and between vascular endothelial growth factor and maximum velocity (P=0·03 and r=0·3913). CLINICAL SIGNIFICANCE: Doppler evaluation may be used to predict malignancy of mammary tumours in bitches.
Authors: Iacopo Vannozzi; Matteo Tesi; Marta Zangheri; Viola Maria Innocenti; Alessandra Rota; Simonetta Citi; Alessandro Poli Journal: Vet Res Commun Date: 2018-03-14 Impact factor: 2.459
Authors: Marcella Massimini; Alessia Gloria; Mariarita Romanucci; Leonardo Della Salda; Lucia Di Francesco; Alberto Contri Journal: Vet Sci Date: 2022-09-15