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Literature DB >> 22644657

Bidirectional photocontrol of peptide conformation with a bridged azobenzene derivative.

Subhas Samanta¹, Chuanguang Qin, Alan J Lough, G Andrew Woolley.

Abstract

It goes both ways: A thiol-reactive cross-linker based on a bridged azobenzene derivative permits photoreversible control of peptide conformation on irradiation with violet (407 nm) and green (500-550 nm) light (see picture) through isomerization of the cross-linker. The large separation of the absorbance bands of the cis (yellow) and trans (red) isomers enables complete bidirectional photoswitching.

Entities: Chemical

Mesh：

Substances：

Year: 2012 PMID： 22644657 DOI： 10.1002/anie.201202383

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

20 in total

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2. New molecular switch architectures.

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Journal: Proc Natl Acad Sci U S A Date: 2018-07-16 Impact factor: 11.205

3. Locked-Azobenzene: Testing the Scope of a Unique Photoswitchable Scaffold for Cell Physiology.

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Journal: ACS Chem Neurosci Date: 2019-02-15 Impact factor: 4.418

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Journal: ChemistryOpen Date: 2019-06-21 Impact factor: 2.911

5. Substituted Dibenzodiazocines: Rapid Synthesis and Photochemical Properties.

Authors: Felix Klockmann; Camilla Fangmann; Elena Zender; Tobias Schanz; Claudia Catapano; Andreas Terfort
Journal: ACS Omega Date: 2021-07-08

6. Azobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner.

Authors: Zhiping Xu; Lina Shi; Danping Jiang; Jiagao Cheng; Xusheng Shao; Zhong Li
Journal: Sci Rep Date: 2015-10-05 Impact factor: 4.379

Bidirectional photocontrol of peptide conformation with a bridged azobenzene derivative.

1. Tightening up the structure, lighting up the pathway: Application of molecular constraints and light to manipulate protein folding, self-assembly and function.

2. New molecular switch architectures.

3. Locked-Azobenzene: Testing the Scope of a Unique Photoswitchable Scaffold for Cell Physiology.

4. Synthesis of Functionalized Azobiphenyl- and Azoterphenyl- Ditopic Linkers: Modular Building Blocks for Photoresponsive Smart Materials.

5. Substituted Dibenzodiazocines: Rapid Synthesis and Photochemical Properties.

6. Azobenzene Modified Imidacloprid Derivatives as Photoswitchable Insecticides: Steering Molecular Activity in a Controllable Manner.

Review 7. Photoresponsive molecular tools for emerging applications of light in medicine.

8. Active Ester Functionalized Azobenzenes as Versatile Building Blocks.

9. High-contrast fluorescence imaging in fixed and living cells using optimized optical switches.

10. Light-Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy.