Literature DB >> 22644032

Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa.

Rasmus Lykke Marvig1, Mette S R Søndergaard, Søren Damkiær, Niels Høiby, Helle Krogh Johansen, Søren Molin, Lars Jelsbak.   

Abstract

The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.

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Year:  2012        PMID： 22644032      PMCID： PMC3421623          DOI： 10.1128/AAC.00630-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  Macrolide resistance conferred by base substitutions in 23S rRNA.

Authors:  B Vester; S Douthwaite
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

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Authors:  B W Holloway; V Krishnapillai; A F Morgan
Journal:  Microbiol Rev       Date:  1979-03

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6.  Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in gram-negative bacteria.

Authors:  M Herrero; V de Lorenzo; K N Timmis
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7.  Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage.

Authors:  A Tait-Kamradt; T Davies; M Cronan; M R Jacobs; P C Appelbaum; J Sutcliffe
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8.  Ribosome protection prevents azithromycin-mediated quorum-sensing modulation and stationary-phase killing of Pseudomonas aeruginosa.

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Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

9.  Long-term azitromycin treatment of cystic fibrosis patients with chronic Pseudomonas aeruginosa infection; an observational cohort study.

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Journal:  J Cyst Fibros       Date:  2005-03       Impact factor: 5.482

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2.  Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.

Authors:  C A Colque; A G Albarracín Orio; S Feliziani; R L Marvig; A R Tobares; H K Johansen; S Molin; A M Smania
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Journal:  Nat Genet       Date:  2015-05-11       Impact factor: 38.330

4.  Azithromycin Exhibits Activity Against Pseudomonas aeruginosa in Chronic Rat Lung Infection Model.

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5.  Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients.

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Review 6.  Responses of Pseudomonas aeruginosa to antimicrobials.

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7.  Genome analysis of a transmissible lineage of pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators.

Authors:  Rasmus Lykke Marvig; Helle Krogh Johansen; Søren Molin; Lars Jelsbak
Journal:  PLoS Genet       Date:  2013-09-05       Impact factor: 5.917

Review 8.  Evolution and impact of bacterial drug resistance in the context of cystic fibrosis disease and nosocomial settings.

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Journal:  Microbiol Insights       Date:  2013-04-14

9.  Within-host evolution of Pseudomonas aeruginosa reveals adaptation toward iron acquisition from hemoglobin.

Authors:  Rasmus Lykke Marvig; Søren Damkiær; S M Hossein Khademi; Trine M Markussen; Søren Molin; Lars Jelsbak
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10.  Is genotyping of single isolates sufficient for population structure analysis of Pseudomonas aeruginosa in cystic fibrosis airways?

Authors:  Lea M Sommer; Rasmus L Marvig; Adela Luján; Anna Koza; Tacjana Pressler; Søren Molin; Helle K Johansen
Journal:  BMC Genomics       Date:  2016-08-09       Impact factor: 3.969
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