| Literature DB >> 25961941 |
Vanessa K Wong1, Stephen Baker2, Derek J Pickard3, Julian Parkhill3, Andrew J Page3, Nicholas A Feasey4, Robert A Kingsley5, Nicholas R Thomson6, Jacqueline A Keane3, François-Xavier Weill7, David J Edwards8, Jane Hawkey9, Simon R Harris3, Alison E Mather3, Amy K Cain3, James Hadfield3, Peter J Hart10, Nga Tran Vu Thieu11, Elizabeth J Klemm3, Dafni A Glinos3, Robert F Breiman12, Conall H Watson13, Samuel Kariuki14, Melita A Gordon15, Robert S Heyderman16, Chinyere Okoro3, Jan Jacobs17, Octavie Lunguya18, W John Edmunds13, Chisomo Msefula19, Jose A Chabalgoity20, Mike Kama21, Kylie Jenkins22, Shanta Dutta23, Florian Marks24, Josefina Campos25, Corinne Thompson26, Stephen Obaro27, Calman A MacLennan28, Christiane Dolecek29, Karen H Keddy30, Anthony M Smith30, Christopher M Parry31, Abhilasha Karkey32, E Kim Mulholland33, James I Campbell26, Sabina Dongol32, Buddha Basnyat32, Muriel Dufour34, Don Bandaranayake35, Take Toleafoa Naseri36, Shalini Pravin Singh37, Mochammad Hatta38, Paul Newton39, Robert S Onsare40, Lupeoletalalei Isaia41, David Dance39, Viengmon Davong42, Guy Thwaites26, Lalith Wijedoru43, John A Crump44, Elizabeth De Pinna45, Satheesh Nair45, Eric J Nilles46, Duy Pham Thanh11, Paul Turner47, Sona Soeng48, Mary Valcanis49, Joan Powling49, Karolina Dimovski49, Geoff Hogg49, Jeremy Farrar26, Kathryn E Holt8, Gordon Dougan3.
Abstract
The emergence of multidrug-resistant (MDR) typhoid is a major global health threat affecting many countries where the disease is endemic. Here whole-genome sequence analysis of 1,832 Salmonella enterica serovar Typhi (S. Typhi) identifies a single dominant MDR lineage, H58, that has emerged and spread throughout Asia and Africa over the last 30 years. Our analysis identifies numerous transmissions of H58, including multiple transfers from Asia to Africa and an ongoing, unrecognized MDR epidemic within Africa itself. Notably, our analysis indicates that H58 lineages are displacing antibiotic-sensitive isolates, transforming the global population structure of this pathogen. H58 isolates can harbor a complex MDR element residing either on transmissible IncHI1 plasmids or within multiple chromosomal integration sites. We also identify new mutations that define the H58 lineage. This phylogeographical analysis provides a framework to facilitate global management of MDR typhoid and is applicable to similar MDR lineages emerging in other bacterial species.Entities:
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Year: 2015 PMID： 25961941 PMCID： PMC4921243 DOI： 10.1038/ng.3281
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330