D G T Whitehurst1, V K Noonan, M F S Dvorak, S Bryan. 1. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. david.whitehurst@ubc.ca
Abstract
STUDY DESIGN: Systematic review. OBJECTIVES: Review the use of generic preference-based measures of health-related quality of life (HRQoL) within the context of spinal cord injury (SCI). METHODS: A systematic search was conducted to identify SCI-related publications that contained any of the following preference-based HRQoL instruments: 15D, Assessment of Quality of Life (AQoL)-4D, AQoL-6D, EQ-5D, EQ-5D-5L, Health Utilities Index (HUI)-2, HUI-3, Quality of Well-Being Scale Self-Administered (QWB-SA), SF-6D(SF-36) or SF-6D(SF-12). In addition to providing an overview of how different preference-based measures have been adopted in SCI research to-date, a focus of evaluation was to collate and appraise evidence for measurement properties and identify knowledge gaps. RESULTS: Twenty-two articles were identified. No studies have used preference-based measures in their conventional form, that is, to calculate quality-adjusted life years using patient-level data. Eleven papers reported mean utility scores (across six different instruments). Directly comparable data exists for only one SCI-specific sample, which showed variation across EQ-5D (0.63), HUI-2 (0.81) and HUI-3 (0.68) index scores. Indirect comparisons suggested differences between QWB-SA and SF-6D index scores within tetraplegic and paraplegic patient groups. Only the QWB-SA and SF-6D have undergone (partial) psychometric evaluation, with the respective authors concluding that the measures have potential for SCI research. CONCLUSIONS: Despite 'cost-effectiveness' being an increasingly important consideration for decision makers in all areas of health care, there is a distinct lack of conceptual or empirical research regarding the appropriateness of alternative preference-based HRQoL measures for SCI populations. Given the support for economic evaluation within a cost-utility framework and the paucity of psychometric evidence regarding current instruments, further research is needed.
STUDY DESIGN: Systematic review. OBJECTIVES: Review the use of generic preference-based measures of health-related quality of life (HRQoL) within the context of spinal cord injury (SCI). METHODS: A systematic search was conducted to identify SCI-related publications that contained any of the following preference-based HRQoL instruments: 15D, Assessment of Quality of Life (AQoL)-4D, AQoL-6D, EQ-5D, EQ-5D-5L, Health Utilities Index (HUI)-2, HUI-3, Quality of Well-Being Scale Self-Administered (QWB-SA), SF-6D(SF-36) or SF-6D(SF-12). In addition to providing an overview of how different preference-based measures have been adopted in SCI research to-date, a focus of evaluation was to collate and appraise evidence for measurement properties and identify knowledge gaps. RESULTS: Twenty-two articles were identified. No studies have used preference-based measures in their conventional form, that is, to calculate quality-adjusted life years using patient-level data. Eleven papers reported mean utility scores (across six different instruments). Directly comparable data exists for only one SCI-specific sample, which showed variation across EQ-5D (0.63), HUI-2 (0.81) and HUI-3 (0.68) index scores. Indirect comparisons suggested differences between QWB-SA and SF-6D index scores within tetraplegic and paraplegic patient groups. Only the QWB-SA and SF-6D have undergone (partial) psychometric evaluation, with the respective authors concluding that the measures have potential for SCI research. CONCLUSIONS: Despite 'cost-effectiveness' being an increasingly important consideration for decision makers in all areas of health care, there is a distinct lack of conceptual or empirical research regarding the appropriateness of alternative preference-based HRQoL measures for SCI populations. Given the support for economic evaluation within a cost-utility framework and the paucity of psychometric evidence regarding current instruments, further research is needed.
Authors: David G T Whitehurst; Nicole Mittmann; Vanessa K Noonan; Marcel F Dvorak; Stirling Bryan Journal: Qual Life Res Date: 2016-04-20 Impact factor: 4.147
Authors: M Arora; L A Harvey; J V Glinsky; H S Chhabra; S Hossain; N Arumugam; P K Bedi; L Lavrencic; A J Hayes; I D Cameron Journal: Spinal Cord Date: 2016-12-20 Impact factor: 2.772
Authors: Lidia Engel; Stirling Bryan; Silvia M A A Evers; Carmen D Dirksen; Vanessa K Noonan; David G T Whitehurst Journal: Qual Life Res Date: 2014-04-04 Impact factor: 4.147
Authors: Mohit Arora; Lisa A Harvey; Joanne V Glinsky; Lianne Nier; Lucija Lavrencic; Annette Kifley; Ian D Cameron Journal: Cochrane Database Syst Rev Date: 2020-01-22