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Literature DB >> 22638859

Detection of autoantibodies and increased concentrations of interleukins in plasma from patients with Tourette's syndrome.

Yu-hang Cheng¹, Yi Zheng, Fan He, Jian-hong Yang, Wen-biao Li, Min-ling Wang, De-yan Cui, Ying Chen.

Abstract

The aim of this study was to assess levels of autoantibodies and cytokines in patients with Tourette's syndrome (TS, n = 40) and healthy control individuals (n = 40). Plasma interleukin (IL)-1β, IL-6, IL-17, and soluble gp130 concentrations were significantly higher in the TS group compared with the control group (P < 0.001); whereas the soluble IL-6 receptor concentration was significantly decreased in the TS group compared with the control group (P < 0.001). Significantly more patients in the TS group were positive for antibrain and antinuclear antibodies, and antistreptolysin compared with the control group (P < 0.05). These findings suggest that immune activity is altered in patients with TS.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22638859 DOI： 10.1007/s12031-012-9811-8

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

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