Literature DB >> 26266339

The usefulness of immunotherapy in pediatric neurodegenerative disorders: A systematic review of literature data.

Giovanna Vitaliti1, Omidreza Tabatabaie2, Nassim Matin2, Caterina Ledda3, Piero Pavone1, Riccardo Lubrano4, Agostino Serra5, Paola Di Mauro5, Salvatore Cocuzza5, Raffaele Falsaperla1.   

Abstract

Immunotherapeutic strategies to treat neurodegenerative disorders have inspired the scientific community. The aim of our review is to address the translational aspects of neuroimmunology to describe the efficacy of immunotherapy in the treatment of pediatric neurodegenerative disorders. In the studies we analyzed IVIG were found to be efficient in the treatment of post-streptococcal neurodegenerative disorders, even if in PANDAS, plasma-exchange (PE) showed a higher efficiency. IVIG were also successfully used in ADEM and Guillan-Barré syndrome. In Sydenham Chorea the use of methylprednisolone was found in most cases as efficient as IVIG, while in Tourette's Syndrome, Colecoxib was successfully used in one patient. Pediatric Multiple Sclerosis seems to respond better to immunosuppressant agents (Mitoxantrone, Cyclophosphamide, Natalizumab), as well as Neuromyelitis optica (Rituximab, Mycofenolate). The importance of this review relies in the attempt to draw standardized guidelines for immunotherapy in pediatric neurodegeneratve disorders.

Entities:  

Keywords:  childhood; immunotherapy-systematic review; neurodegenerative disorders

Mesh：

Substances：

Year:  2015        PMID： 26266339      PMCID： PMC5391617          DOI： 10.1080/21645515.2015.1061161

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  125 in total

1.  Multiphasic demyelinating disease involving central and peripheral nervous system in a child.

Authors:  P Mariotti; A P Batocchi; C Colosimo; M Lo Monaco; M Caggiula; F Colitto; P A Tonali; F Guzzetta
Journal:  Neurology       Date:  2003-01-28       Impact factor: 9.910

2.  Acute disseminated encephalomyelitis treated with plasmapheresis.

Authors:  R RamachandranNair; M Parameswaran; A S Girija
Journal:  Singapore Med J       Date:  2005-10       Impact factor: 1.858

Review 3.  Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for Guillain-Barré syndrome.

Authors:  Richard A C Hughes; Jane Pritchard; Robert D M Hadden
Journal:  Cochrane Database Syst Rev       Date:  2013-02-28

4.  Long-term follow-up of pediatric patients treated with mitoxantrone for multiple sclerosis.

Authors:  B Kornek; G Bernert; K Rostasy; E Mlczoch; M Feucht; D Prayer; K Vass; R Seidl
Journal:  Neuropediatrics       Date:  2011-05-09       Impact factor: 1.947

5.  Plasma exchange in episodes of severe inflammatory demyelination of the central nervous system. A report of six cases.

Authors:  Luke Bennetto; April Totham; Pat Healy; Edwin Massey; Neil Scolding
Journal:  J Neurol       Date:  2004-12       Impact factor: 4.849

6.  Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood.

Authors:  S J Perlmutter; S F Leitman; M A Garvey; S Hamburger; E Feldman; H L Leonard; S E Swedo
Journal:  Lancet       Date:  1999-10-02       Impact factor: 79.321

7.  Cyclophosphamide therapy in pediatric multiple sclerosis.

Authors:  N Makhani; M P Gorman; H M Branson; L Stazzone; B L Banwell; T Chitnis
Journal:  Neurology       Date:  2009-05-13       Impact factor: 9.910

8.  Natalizumab use in pediatric multiple sclerosis.

Authors:  Peter Huppke; Wiebke Stark; Claudia Zürcher; Brenda Huppke; Wolfgang Brück; Jutta Gärtner
Journal:  Arch Neurol       Date:  2008-12

9.  Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis.

Authors:  Asa Andersson; Ruxandra Covacu; Dan Sunnemark; Alexandre I Danilov; Assunta Dal Bianco; Mohsen Khademi; Erik Wallström; Anna Lobell; Lou Brundin; Hans Lassmann; Robert A Harris
Journal:  J Leukoc Biol       Date:  2008-07-21       Impact factor: 4.962

10.  Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process.

Authors:  Stefania Mantovani; Silvia Garbelli; Alessandra Pasini; Dario Alimonti; Cesare Perotti; Mario Melazzini; Caterina Bendotti; Gabriele Mora
Journal:  J Neuroimmunol       Date:  2009-05-29       Impact factor: 3.478
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  8 in total

Review 1.  Childhood neurofibromatosis type 2 (NF2) and related disorders: from bench to bedside and biologically targeted therapies.

Authors:  M Ruggieri; A D Praticò; A Serra; L Maiolino; S Cocuzza; P Di Mauro; L Licciardello; P Milone; G Privitera; G Belfiore; M Di Pietro; F Di Raimondo; A Romano; A Chiarenza; M Muglia; A Polizzi; D G Evans
Journal:  Acta Otorhinolaryngol Ital       Date:  2016-10       Impact factor: 2.124

2.  Autoimmune Ear Disease: Clinical and Diagnostic Relevance in Cogan's Sydrome.

Authors:  Luigi Maiolino; Salvatore Cocuzza; Angelo Conti; Luisa Licciardello; Agostino Serra; Salvatore Gallina
Journal:  Audiol Res       Date:  2017-03-30

3.  Identification of ultra-rare genetic variants in pediatric acute onset neuropsychiatric syndrome (PANS) by exome and whole genome sequencing.

Authors:  Rosario Trifiletti; Herbert M Lachman; Olivia Manusama; Deyou Zheng; Alberto Spalice; Pietro Chiurazzi; Allan Schornagel; Andreea M Serban; Rogier van Wijck; Janet L Cunningham; Sigrid Swagemakers; Peter J van der Spek
Journal:  Sci Rep       Date:  2022-06-30       Impact factor: 4.996

4.  Adaptive psychological structure in childhood hearing impairment: audiological correlations.

Authors:  A Serra; G Spinato; S Cocuzza; L Licciardello; P Pavone; L Maiolino
Journal:  Acta Otorhinolaryngol Ital       Date:  2017-06       Impact factor: 2.124

5.  Altered cerebral glucose metabolism normalized in a patient with a pediatric autoimmune neuropsychiatric disorder after streptococcal infection (PANDAS)-like condition following treatment with plasmapheresis: a case report.

Authors:  A H Nave; P Harmel; R Buchert; L Harms
Journal:  BMC Neurol       Date:  2018-05-02       Impact factor: 2.474

6.  Neuropsychiatric Disorder Associated with Group G Streptococcus Infection.

Authors:  Rie Okumura; Sawako Yamazaki; Tsukasa Ohashi; Shinichi Magara; Jun Tohyama; Hiroshi Sakuma; Masaharu Hayashi; Akihiko Saitoh
Journal:  Case Rep Pediatr       Date:  2018-09-23

7.  Initial Response and Outcome of Critically Ill Children With Guillain Barre' Syndrome.

Authors:  Hafez M Bazaraa; Hanaa I Rady; Shereen A Mohamed; Walaa A Rabie; Noha H ElAnwar
Journal:  Front Pediatr       Date:  2019-09-18       Impact factor: 3.418

8.  The effectiveness and safety of acupuncture therapy for Guillain-Barré syndrome: A systematic review and meta-analysis protocol.

Authors:  Zhu Fan; Biyuan Liu; Yili Zhang; Man Li; Tao Lu
Journal:  Medicine (Baltimore)       Date:  2020-01       Impact factor: 1.817
  8 in total

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