Literature DB >> 22634495

MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cells.

Mei-Jing Long1, Fu-Xia Wu, Pu Li, Min Liu, Xin Li, Hua Tang.   

Abstract

MicroRNAs (miRNAs) play an important role in cancer initiation, progression and metastasis by regulating their target genes. Here, we found microRNA-10a (miR-10a) is upregulated in human cervical cancer and promotes the colony formation activity, migration and invasion of HeLa and C33A cells. Subsequently, CHL1 is confirmed as a target of miR-10a and is negatively regulated by miR-10a at mRNA and protein levels. Furthermore, knockdown of CHL1 expression results in increased colony formation activity, migration and invasion. Finally, overexpression of CHL1 lacked the 3'UTR abolished the effects of miR-10a. Our results may provide a strategy for blocking tumor metastasis.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Year:  2012        PMID： 22634495     DOI： 10.1016/j.canlet.2012.05.022

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  57 in total

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Journal:  Oncol Lett       Date:  2015-09-29       Impact factor: 2.967

2.  XRN2 promotes EMT and metastasis through regulating maturation of miR-10a.

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Journal:  Oncogene       Date:  2017-03-20       Impact factor: 9.867

3.  miR-346 Up-regulates Argonaute 2 (AGO2) Protein Expression to Augment the Activity of Other MicroRNAs (miRNAs) and Contributes to Cervical Cancer Cell Malignancy.

Authors:  Junfei Guo; Jing Lv; Min Liu; Hua Tang
Journal:  J Biol Chem       Date:  2015-10-30       Impact factor: 5.157

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Journal:  Tumour Biol       Date:  2014-02-20

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Authors:  Yuqi Guo; Peng Tian; Chuanhe Yang; Zhibing Liang; Min Li; Michelle Sims; Lu Lu; Zhan Zhang; Hongwei Li; Lawrence M Pfeffer; Junming Yue
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6.  miR-519d-3p Inhibits Cell Proliferation and Invasion of Gastric Cancer by Downregulating B-Cell Lymphoma 6.

Authors:  Yong-Yuan Li; Jian-Ping Shao; Shu-Peng Zhang; Guo-Qiang Xing; Hong-Jie Liu
Journal:  Cytogenet Genome Res       Date:  2018-03-07       Impact factor: 1.636

7.  Expression of microRNA-10a, microRNA-342-3p and their predicted target gene TIAM1 in extranodal NK/T-cell lymphoma, nasal type.

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Journal:  Oncol Lett       Date:  2015-10-27       Impact factor: 2.967

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9.  MicroRNA-361-5p facilitates cervical cancer progression through mediation of epithelial-to-mesenchymal transition.

Authors:  Xiaomei Wu; Xiaowei Xi; Qin Yan; Zhenbo Zhang; Bin Cai; Wen Lu; Xiaoping Wan
Journal:  Med Oncol       Date:  2013-10-26       Impact factor: 3.064

10.  MiR-214 inhibits cell migration, invasion and promotes the drug sensitivity in human cervical cancer by targeting FOXM1.

Authors:  Jian-Mei Wang; Bao-Hui Ju; Cai-Jun Pan; Yan Gu; Meng-Qi Li; Li Sun; Yan-Ying Xu; Li-Rong Yin
Journal:  Am J Transl Res       Date:  2017-08-15       Impact factor: 4.060
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