Literature DB >> 26788134

Function and clinical potential of microRNAs in hepatocellular carcinoma.

Lijuan Wang1, Yongfang Yue2, Xian Wang2, Hongchuan Jin2.   

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs involved in the initiation and progression of several types of human cancer, including hepatocellular carcinoma (HCC), which is one of the most common types of cancer and the third leading cause of cancer-related mortality worldwide. Mounting evidence has demonstrated that miRNAs play a vital role in HCC, hepatitis, alcoholic liver disease, liver cell development and the metabolic functions of the liver. The aim of the present review was to summarize the most recent findings on the functions of miRNAs in the liver and discuss their potential roles in the diagnosis, prognosis and treatment of HCC.

Entities:  

Keywords:  diagnosis; hepatocellular carcinoma; microRNA; prognosis; therapy

Year:  2015        PMID： 26788134      PMCID： PMC4665873          DOI： 10.3892/ol.2015.3759

Source DB:  PubMed          Journal:  Oncol Lett        ISSN： 1792-1074            Impact factor:   2.967


  157 in total

1.  MicroRNA genes are transcribed by RNA polymerase II.

Authors:  Yoontae Lee; Minju Kim; Jinju Han; Kyu-Hyun Yeom; Sanghyuk Lee; Sung Hee Baek; V Narry Kim
Journal:  EMBO J       Date:  2004-09-16       Impact factor: 11.598

2.  miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma.

Authors:  H M El Tayebi; K A Hosny; G Esmat; K Breuhahn; Ahmed Ihab Abdelaziz
Journal:  FEBS Lett       Date:  2012-07-20       Impact factor: 4.124

3.  Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer.

Authors:  Xueqing Wang; Jiandong Wang; Henghui Ma; Jin Zhang; Xiaojun Zhou
Journal:  Med Oncol       Date:  2011-03-10       Impact factor: 3.064

Review 4.  Hepatocellular carcinoma.

Authors:  Alejandro Forner; Josep M Llovet; Jordi Bruix
Journal:  Lancet       Date:  2012-02-20       Impact factor: 79.321

5.  miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma.

Authors:  Qin Zhu; Zhiming Wang; Yu Hu; Jindong Li; Xinying Li; Ledu Zhou; Yun Huang
Journal:  Oncol Rep       Date:  2012-02-09       Impact factor: 3.906

6.  Identification and characterization of tumorigenic liver cancer stem/progenitor cells.

Authors:  Stephanie Ma; Kwok-Wah Chan; Liang Hu; Terence Kin-Wah Lee; Jana Yim-Hung Wo; Irene Oi-Lin Ng; Bo-Jian Zheng; Xin-Yuan Guan
Journal:  Gastroenterology       Date:  2007-04-15       Impact factor: 22.682

7.  MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells.

Authors:  Teng Xu; Ying Zhu; Yujuan Xiong; Yi-Yuan Ge; Jing-Ping Yun; Shi-Mei Zhuang
Journal:  Hepatology       Date:  2009-07       Impact factor: 17.425

8.  Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma.

Authors:  Laura Gramantieri; Manuela Ferracin; Francesca Fornari; Angelo Veronese; Silvia Sabbioni; Chang-Gong Liu; George A Calin; Catia Giovannini; Eros Ferrazzi; Gian Luca Grazi; Carlo M Croce; Luigi Bolondi; Massimo Negrini
Journal:  Cancer Res       Date:  2007-07-01       Impact factor: 12.701

9.  Suppression of non-small cell lung tumor development by the let-7 microRNA family.

Authors:  Madhu S Kumar; Stefan J Erkeland; Ryan E Pester; Cindy Y Chen; Margaret S Ebert; Phillip A Sharp; Tyler Jacks
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-28       Impact factor: 11.205

10.  A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells.

Authors:  Andrew Hinton; Ivka Afrikanova; Mike Wilson; Charles C King; Brian Maurer; Gene W Yeo; Alberto Hayek; Amy E Pasquinelli
Journal:  Stem Cells Dev       Date:  2010-06       Impact factor: 3.272
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  10 in total

1.  MicroRNAs are key regulators of hepatocellular carcinoma (HCC) cell dissemination-what we learned from microRNA-494.

Authors:  Margarita González-Vallinas; Kai Breuhahn
Journal:  Hepatobiliary Surg Nutr       Date:  2016-08       Impact factor: 7.293

Review 2.  Hepatocellular Carcinoma: The Role of MicroRNAs.

Authors:  Sharad Khare; Tripti Khare; Raghu Ramanathan; Jamal A Ibdah
Journal:  Biomolecules       Date:  2022-04-27

3.  microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.

Authors:  Sanchari Roy; Guido J Hooiveld; Marco Seehawer; Stefano Caruso; Florian Heinzmann; Anne T Schneider; Anna K Frank; David Vargas Cardenas; Roland Sonntag; Mark Luedde; Christian Trautwein; Ilan Stein; Eli Pikarsky; Sven Loosen; Frank Tacke; Marc Ringelhan; Seda Kilinc Avsaroglu; Andrei Goga; Marie-Annick Buendia; Mihael Vucur; Mathias Heikenwalder; Jessica Zucman-Rossi; Lars Zender; Christoph Roderburg; Tom Luedde
Journal:  Gastroenterology       Date:  2018-08-27       Impact factor: 22.682

4.  Low folate levels are associated with methylation-mediated transcriptional repression of miR-203 and miR-375 during cervical carcinogenesis.

Authors:  Min Hao; Weihong Zhao; Lili Zhang; Honghong Wang; Xin Yang
Journal:  Oncol Lett       Date:  2016-04-18       Impact factor: 2.967

5.  Mechanistic roles of microRNAs in hepatocarcinogenesis: A study of thioacetamide with multiple doses and time-points of rats.

Authors:  Harsh Dweep; Yuji Morikawa; Binsheng Gong; Jian Yan; Zhichao Liu; Tao Chen; Halil Bisgin; Wen Zou; Huixiao Hong; Tieliu Shi; Ping Gong; Christina Castro; Takeki Uehara; Yuping Wang; Weida Tong
Journal:  Sci Rep       Date:  2017-06-08       Impact factor: 4.379

6.  Lymphocyte-specific protein 1 inhibits the growth of hepatocellular carcinoma by suppressing ERK1/2 phosphorylation.

Authors:  Hongyong Zhang; Yufeng Wang; Zhikui Liu; Bowen Yao; Changwei Dou; Meng Xu; Qing Li; Yuli Jia; Shengli Wu; Kangsheng Tu; Qingguang Liu
Journal:  FEBS Open Bio       Date:  2016-11-07       Impact factor: 2.693

7.  Pleiotrophin, a target of miR-384, promotes proliferation, metastasis and lipogenesis in HBV-related hepatocellular carcinoma.

Authors:  Pei-Song Bai; Nan Xia; Hong Sun; Ying Kong
Journal:  J Cell Mol Med       Date:  2017-05-30       Impact factor: 5.310

8.  Inhibition of microRNA-126 promotes the expression of Spred1 to inhibit angiogenesis in hepatocellular carcinoma after transcatheter arterial chemoembolization: in vivo study.

Authors:  Jian-Song Ji; Min Xu; Jing-Jing Song; Zhong-Wei Zhao; Min-Jiang Chen; Wei-Qian Chen; Jian-Fei Tu; Xiao-Ming Yang
Journal:  Onco Targets Ther       Date:  2016-07-19       Impact factor: 4.147

9.  Extract of Stellerachamaejasme L(ESC) inhibits growth and metastasis of human hepatocellular carcinoma via regulating microRNA expression.

Authors:  Xiaoni Liu; Shuang Wang; Jianji Xu; Buxin Kou; Dexi Chen; Yajie Wang; Xiaoxin Zhu
Journal:  BMC Complement Altern Med       Date:  2018-03-20       Impact factor: 3.659

10.  miR-146a Inhibits Proliferation and Enhances Chemosensitivity in Epithelial Ovarian Cancer via Reduction of SOD2.

Authors:  YaJie Cui; Kai'e She; Defu Tian; Peilian Zhang; Xiaoyan Xin
Journal:  Oncol Res       Date:  2016       Impact factor: 5.574
  10 in total

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