| Literature DB >> 22632721 |
Olaf Bergmann1, Jakob Liebl, Samuel Bernard, Kanar Alkass, Maggie S Y Yeung, Peter Steier, Walter Kutschera, Lars Johnson, Mikael Landén, Henrik Druid, Kirsty L Spalding, Jonas Frisén.
Abstract
Continuous turnover of neurons in the olfactory bulb is implicated in several key aspects of olfaction. There is a dramatic decline postnatally in the number of migratory neuroblasts en route to the olfactory bulb in humans, and it has been unclear to what extent the small number of neuroblasts at later stages contributes new neurons to the olfactory bulb. We have assessed the age of olfactory bulb neurons in humans by measuring the levels of nuclear bomb test-derived (14)C in genomic DNA. We report that (14)C concentrations correspond to the atmospheric levels at the time of birth of the individuals, establishing that there is very limited, if any, postnatal neurogenesis in the human olfactory bulb. This identifies a fundamental difference in the plasticity of the human brain compared to other mammals.Entities:
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Year: 2012 PMID： 22632721 DOI： 10.1016/j.neuron.2012.03.030
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173