Literature DB >> 22628210

Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine.

Laura E McNamara1, Terje Sjöström, R M Dominic Meek, Richard O C Oreffo, Bo Su, Matthew J Dalby, Karl E V Burgess.   

Abstract

Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.

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Year:  2012        PMID： 22628210      PMCID： PMC3385772          DOI： 10.1098/rsif.2012.0169

Source DB:  PubMed          Journal:  J R Soc Interface        ISSN： 1742-5662            Impact factor:   4.118


  31 in total

1.  Characterization and multipotentiality of human fetal femur-derived cells: implications for skeletal tissue regeneration.

Authors:  Sayed-Hadi Mirmalek-Sani; Rahul S Tare; Suzanne M Morgan; Helmtrud I Roach; David I Wilson; Neil A Hanley; Richard O C Oreffo
Journal:  Stem Cells       Date:  2005-12-22       Impact factor: 6.277

2.  Matrix elasticity directs stem cell lineage specification.

Authors:  Adam J Engler; Shamik Sen; H Lee Sweeney; Dennis E Discher
Journal:  Cell       Date:  2006-08-25       Impact factor: 41.582

Review 3.  Identification of small molecules from human embryonic stem cells using metabolomics.

Authors:  Gabriela G Cezar; Jessica A Quam; Alan M Smith; Guilherme J M Rosa; Marian S Piekarczyk; James F Brown; Fred H Gage; Alysson R Muotri
Journal:  Stem Cells Dev       Date:  2007-12       Impact factor: 3.272

Review 4.  Fluorescence two-dimensional difference gel electrophoresis for biomaterial applications.

Authors:  Laura E McNamara; Matthew J Dalby; Mathis O Riehle; Richard Burchmore
Journal:  J R Soc Interface       Date:  2009-07-01       Impact factor: 4.118

5.  PeakML/mzMatch: a file format, Java library, R library, and tool-chain for mass spectrometry data analysis.

Authors:  Richard A Scheltema; Andris Jankevics; Ritsert C Jansen; Morris A Swertz; Rainer Breitling
Journal:  Anal Chem       Date:  2011-03-14       Impact factor: 6.986

6.  Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction.

Authors:  Darren J Creek; Andris Jankevics; Rainer Breitling; David G Watson; Michael P Barrett; Karl E V Burgess
Journal:  Anal Chem       Date:  2011-10-21       Impact factor: 6.986

7.  High sensitivity collisionally-activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal-acceleration time-of-flight mass spectrometer.

Authors:  H R Morris; T Paxton; A Dell; J Langhorne; M Berg; R S Bordoli; J Hoyes; R H Bateman
Journal:  Rapid Commun Mass Spectrom       Date:  1996       Impact factor: 2.419

8.  Characterisation of human embryonic stem cells conditioning media by 1H-nuclear magnetic resonance spectroscopy.

Authors:  David A MacIntyre; Darío Melguizo Sanchís; Beatriz Jiménez; Rubén Moreno; Miodrag Stojkovic; Antonio Pineda-Lucena
Journal:  PLoS One       Date:  2011-02-09       Impact factor: 3.240

9.  Preventing and troubleshooting artefacts in saturation labelled fluorescence 2-D difference gel electrophoresis (saturation DiGE).

Authors:  Laura E McNamara; Fahsai A Kantawong; Matthew J Dalby; Mathis O Riehle; Richard Burchmore
Journal:  Proteomics       Date:  2011-11-23       Impact factor: 3.984

10.  Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry.

Authors:  David P Leader; Karl Burgess; Darren Creek; Michael P Barrett
Journal:  Rapid Commun Mass Spectrom       Date:  2011-11-30       Impact factor: 2.419
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  9 in total

Review 1.  Metabolomics in the studies of islet autoimmunity and type 1 diabetes.

Authors:  Matej Oresic
Journal:  Rev Diabet Stud       Date:  2012-12-28

Review 2.  Computational tools for the secondary analysis of metabolomics experiments.

Authors:  Sean C Booth; Aalim M Weljie; Raymond J Turner
Journal:  Comput Struct Biotechnol J       Date:  2013-02-06       Impact factor: 7.271

Review 3.  The stem cell secretome and its role in brain repair.

Authors:  Denise Drago; Chiara Cossetti; Nunzio Iraci; Edoardo Gaude; Giovanna Musco; Angela Bachi; Stefano Pluchino
Journal:  Biochimie       Date:  2013-07-01       Impact factor: 4.079

4.  Metabolomics Analysis of the Osteogenic Differentiation of Umbilical Cord Blood Mesenchymal Stem Cells Reveals Differential Sensitivity to Osteogenic Agents.

Authors:  Michail E Klontzas; Spyros I Vernardis; Manolis Heliotis; Eleftherios Tsiridis; Athanasios Mantalaris
Journal:  Stem Cells Dev       Date:  2017-04-18       Impact factor: 3.272

5.  The Impact of GFP Reporter Gene Transduction and Expression on Metabolomics of Placental Mesenchymal Stem Cells Determined by UHPLC-Q/TOF-MS.

Authors:  Jinfeng Yang; Nan Wang; Deying Chen; Jiong Yu; Qiaoling Pan; Dan Wang; Jingqi Liu; Xiaowei Shi; Xiaotian Dong; Hongcui Cao; Liang Li; Lanjuan Li
Journal:  Stem Cells Int       Date:  2017-11-05       Impact factor: 5.443

6.  A Metabolomics Approach Reveals Immunomodulatory Effects of Proteinaceous Molecules Derived From Gut Bacteria Over Human Peripheral Blood Mononuclear Cells.

Authors:  Noelia Cambeiro-Pérez; Claudio Hidalgo-Cantabrana; Marco A Moro-García; Rebeca Alonso-Arias; Jesús Simal-Gándara; Borja Sánchez; Elena Martínez-Carballo
Journal:  Front Microbiol       Date:  2018-11-13       Impact factor: 5.640

7.  Metabolomic Analysis Reveals That the Mechanism of Astaxanthin Improves the Osteogenic Differentiation Potential in Bone Marrow Mesenchymal Stem Cells.

Authors:  Guangfeng Zhao; Huiming Zhong; Taiwen Rao; Zhijun Pan
Journal:  Oxid Med Cell Longev       Date:  2020-03-25       Impact factor: 6.543

8.  Validation of Metabolic Alterations in Microscale Cell Culture Lysates Using Hydrophilic Interaction Liquid Chromatography (HILIC)-Tandem Mass Spectrometry-Based Metabolomics.

Authors:  Venugopal Gunda; Fang Yu; Pankaj K Singh
Journal:  PLoS One       Date:  2016-04-27       Impact factor: 3.240

9.  Metabolic determinants of the immune modulatory function of neural stem cells.

Authors:  Denise Drago; Veronica Basso; Edoardo Gaude; Giulio Volpe; Luca Peruzzotti-Jametti; Angela Bachi; Giovanna Musco; Annapaola Andolfo; Christian Frezza; Anna Mondino; Stefano Pluchino
Journal:  J Neuroinflammation       Date:  2016-09-02       Impact factor: 8.322
  9 in total

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