OBJECTIVE: To evaluate the risk factors for new-onset overactive bladder (OAB) in older subjects. METHODS: The present study enrolled 4427 subjects aged ≥ 65 years who had participated in the Fujiwara-kyo study. The prevalence of OAB at baseline and 1 year later was evaluated using the OAB symptom score questionnaire. The incidence and remission rate of OAB were calculated. We identified the risk factors for OAB by evaluating the difference in characteristics (including sex, age, body mass index, life style, comorbidities, depressive status, metabolic syndrome, and sum of voiding symptoms) between those with and without new-onset OAB. In addition, the independent risk factors were determined by multivariate analysis. RESULTS: Of the 4427 subjects, 3685 completely replied to the self-administrated questionnaires at baseline and 1 year later. The incidence and remission rate of OAB was 11.9% and 29.8%, respectively. The male/female ratio, sum of voiding symptoms, alcohol consumption and smoking, hypertension, and depressive status in subjects with new-onset OAB, were significantly greater than those in subjects without new-onset OAB. A multivariate analysis, including sex (odds ratio 2.0, P < .0001), sum of voiding symptoms (odds ratio 1.1, P < .0001), and depressive status (odds ratio 1.8, P < .0001) were independent factors for new-onset OAB in older subjects. CONCLUSION: The results of the present study have demonstrated that male sex, the sum of voiding symptoms, and depression were independent factors for new-onset OAB. It is necessary to determine whether the treatment of patients with voiding symptoms or depression controls for new-onset OAB.
OBJECTIVE: To evaluate the risk factors for new-onset overactive bladder (OAB) in older subjects. METHODS: The present study enrolled 4427 subjects aged ≥ 65 years who had participated in the Fujiwara-kyo study. The prevalence of OAB at baseline and 1 year later was evaluated using the OAB symptom score questionnaire. The incidence and remission rate of OAB were calculated. We identified the risk factors for OAB by evaluating the difference in characteristics (including sex, age, body mass index, life style, comorbidities, depressive status, metabolic syndrome, and sum of voiding symptoms) between those with and without new-onset OAB. In addition, the independent risk factors were determined by multivariate analysis. RESULTS: Of the 4427 subjects, 3685 completely replied to the self-administrated questionnaires at baseline and 1 year later. The incidence and remission rate of OAB was 11.9% and 29.8%, respectively. The male/female ratio, sum of voiding symptoms, alcohol consumption and smoking, hypertension, and depressive status in subjects with new-onset OAB, were significantly greater than those in subjects without new-onset OAB. A multivariate analysis, including sex (odds ratio 2.0, P < .0001), sum of voiding symptoms (odds ratio 1.1, P < .0001), and depressive status (odds ratio 1.8, P < .0001) were independent factors for new-onset OAB in older subjects. CONCLUSION: The results of the present study have demonstrated that male sex, the sum of voiding symptoms, and depression were independent factors for new-onset OAB. It is necessary to determine whether the treatment of patients with voiding symptoms or depression controls for new-onset OAB.
Authors: Aelia Akbar; Kiang Liu; Erin D Michos; Michael P Bancks; Linda Brubaker; Talar Markossian; Ramon Durazo-Arvizu; Holly Kramer Journal: Am J Hypertens Date: 2022-01-05 Impact factor: 2.689
Authors: Larissa R Ferreira; Monica O Gameiro; Paulo R Kawano; Hamilto A Yamamoto; Rodrigo Guerra; Leonardo O Reis; João L Amaro Journal: Int Braz J Urol Date: 2017 Nov-Dec Impact factor: 1.541
Authors: Andrzej Wróbel; Anna Serefko; Aleksandra Szopa; Daniela Ulrich; Ewa Poleszak; Tomasz Rechberger Journal: Front Pharmacol Date: 2020-07-08 Impact factor: 5.810