| Literature DB >> 22623224 |
Susanne Ditlevsen1, Priscilla Greenwood.
Abstract
We show that the stochastic Morris-Lecar neuron, in a neighborhood of its stable point, can be approximated by a two-dimensional Ornstein-Uhlenbeck (OU) modulation of a constant circular motion. The associated radial OU process is an example of a leaky integrate-and-fire (LIF) model prior to firing. A new model constructed from a radial OU process together with a simple firing mechanism based on detailed Morris-Lecar firing statistics reproduces the Morris-Lecar Interspike Interval (ISI) distribution, and has the computational advantages of a LIF. The result justifies the large amount of attention paid to the LIF models.Mesh:
Year: 2012 PMID: 22623224 DOI: 10.1007/s00285-012-0552-7
Source DB: PubMed Journal: J Math Biol ISSN: 0303-6812 Impact factor: 2.259