Literature DB >> 22623224

The Morris-Lecar neuron model embeds a leaky integrate-and-fire model.

Susanne Ditlevsen1, Priscilla Greenwood.   

Abstract

We show that the stochastic Morris-Lecar neuron, in a neighborhood of its stable point, can be approximated by a two-dimensional Ornstein-Uhlenbeck (OU) modulation of a constant circular motion. The associated radial OU process is an example of a leaky integrate-and-fire (LIF) model prior to firing. A new model constructed from a radial OU process together with a simple firing mechanism based on detailed Morris-Lecar firing statistics reproduces the Morris-Lecar Interspike Interval (ISI) distribution, and has the computational advantages of a LIF. The result justifies the large amount of attention paid to the LIF models.

Mesh:

Year:  2012        PMID: 22623224     DOI: 10.1007/s00285-012-0552-7

Source DB:  PubMed          Journal:  J Math Biol        ISSN: 0303-6812            Impact factor:   2.259


  11 in total

1.  A quantitative description of membrane current and its application to conduction and excitation in nerve.

Authors:  A L HODGKIN; A F HUXLEY
Journal:  J Physiol       Date:  1952-08       Impact factor: 5.182

2.  Random dynamics of the Morris-Lecar neural model.

Authors:  Takashi Tateno; Khashayar Pakdaman
Journal:  Chaos       Date:  2004-09       Impact factor: 3.642

3.  Sustained oscillations for density dependent Markov processes.

Authors:  Peter H Baxendale; Priscilla E Greenwood
Journal:  J Math Biol       Date:  2010-11-13       Impact factor: 2.259

4.  Parameter estimation in a stochastic model of the tubuloglomerular feedback mechanism in a rat nephron.

Authors:  Susanne Ditlevsen; Kay-Pong Yip; Niels-Henrik Holstein-Rathlou
Journal:  Math Biosci       Date:  2005-03       Impact factor: 2.144

5.  Optimal spike-timing-dependent plasticity for precise action potential firing in supervised learning.

Authors:  Jean-Pascal Pfister; Taro Toyoizumi; David Barber; Wulfram Gerstner
Journal:  Neural Comput       Date:  2006-06       Impact factor: 2.026

Review 6.  A review of the integrate-and-fire neuron model: I. Homogeneous synaptic input.

Authors:  A N Burkitt
Journal:  Biol Cybern       Date:  2006-04-19       Impact factor: 2.086

7.  Sustained oscillations via coherence resonance in SIR.

Authors:  Rachel Kuske; Luis F Gordillo; Priscilla Greenwood
Journal:  J Theor Biol       Date:  2006-11-03       Impact factor: 2.691

Review 8.  A review of the methods for signal estimation in stochastic diffusion leaky integrate-and-fire neuronal models.

Authors:  Petr Lansky; Susanne Ditlevsen
Journal:  Biol Cybern       Date:  2008-05-22       Impact factor: 2.086

9.  Identification and continuity of the distributions of burst-length and interspike intervals in the stochastic Morris-Lecar neuron.

Authors:  Peter F Rowat; Priscilla E Greenwood
Journal:  Neural Comput       Date:  2011-09-15       Impact factor: 2.026

10.  Voltage oscillations in the barnacle giant muscle fiber.

Authors:  C Morris; H Lecar
Journal:  Biophys J       Date:  1981-07       Impact factor: 4.033

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  4 in total

1.  Sustained oscillations for density dependent Markov processes.

Authors:  Peter H Baxendale; Priscilla E Greenwood
Journal:  J Math Biol       Date:  2010-11-13       Impact factor: 2.259

2.  Minimal time spiking in various ChR2-controlled neuron models.

Authors:  Vincent Renault; Michèle Thieullen; Emmanuel Trélat
Journal:  J Math Biol       Date:  2017-06-29       Impact factor: 2.259

3.  The ISI distribution of the stochastic Hodgkin-Huxley neuron.

Authors:  Peter F Rowat; Priscilla E Greenwood
Journal:  Front Comput Neurosci       Date:  2014-10-08       Impact factor: 2.380

4.  Why noise is useful in functional and neural mechanisms of interval timing?

Authors:  Sorinel A Oprisan; Catalin V Buhusi
Journal:  BMC Neurosci       Date:  2013-08-07       Impact factor: 3.288

  4 in total

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