PURPOSE: Our aim was to evaluate the hepatocyte transporters in focal nodular hyperplasia (FNH) and FNH-like lesions and to correlate the grade of its expression with signal intensity on the hepatobiliary phase (HB phase) of gadoxetic-acid-enhanced magnetic resonance imaging (EOB-MRI). MATERIALS AND METHODS: Thirteen histopathological confirmed cases including eight with EOB-MRI were studied. Immunohistochemical staining for transporter was performed and its grade semiquantitatively analyzed. RESULTS: Histopathologically, ten cases showed almost equal organic anion transporter polypeptide (OATP) 8 expression relative to the surrounding liver; the remaining three showed stronger OATP8 expression. In eight cases with EOB-MRI, two demonstrated more hyperintensity on the HB phase, and their OATP8 expression was stronger compared with the surrounding liver. The remaining six cases showed isointensity on the HB phase and revealed almost equal OATP8 expression. The expression of export transporter multi-drug-resistant proteins (MRP) 1 and 2 were almost equal relative to the surrounding liver in most cases (11/12, 92 %; 11/12, 92 %, respectively), whereas MRP3 focally overexpressed in 75 % (9/12) of cases. CONCLUSION: FNH and FNH-like nodules revealed equal or stronger OATP8 expression than background liver. OATP8 expression showed significant correlation with signal intensity on the HB phase.
PURPOSE: Our aim was to evaluate the hepatocyte transporters in focal nodular hyperplasia (FNH) and FNH-like lesions and to correlate the grade of its expression with signal intensity on the hepatobiliary phase (HB phase) of gadoxetic-acid-enhanced magnetic resonance imaging (EOB-MRI). MATERIALS AND METHODS: Thirteen histopathological confirmed cases including eight with EOB-MRI were studied. Immunohistochemical staining for transporter was performed and its grade semiquantitatively analyzed. RESULTS: Histopathologically, ten cases showed almost equal organic anion transporter polypeptide (OATP) 8 expression relative to the surrounding liver; the remaining three showed stronger OATP8 expression. In eight cases with EOB-MRI, two demonstrated more hyperintensity on the HB phase, and their OATP8 expression was stronger compared with the surrounding liver. The remaining six cases showed isointensity on the HB phase and revealed almost equal OATP8 expression. The expression of export transporter multi-drug-resistant proteins (MRP) 1 and 2 were almost equal relative to the surrounding liver in most cases (11/12, 92 %; 11/12, 92 %, respectively), whereas MRP3 focally overexpressed in 75 % (9/12) of cases. CONCLUSION: FNH and FNH-like nodules revealed equal or stronger OATP8 expression than background liver. OATP8 expression showed significant correlation with signal intensity on the HB phase.
Authors: P Bioulac-Sage; C Balabaud; P Bedossa; J Y Scoazec; L Chiche; A P Dhillon; L Ferrell; V Paradis; T Roskams; V Vilgrain; I R Wanless; J Zucman-Rossi Journal: J Hepatol Date: 2007-01-02 Impact factor: 25.083
Authors: Sara Vander Borght; Louis Libbrecht; Hans Blokzijl; Klaas Nico Faber; Han Moshage; Raymond Aerts; Werner Van Steenbergen; Peter L Jansen; Valeer J Desmet; Tania A Roskams Journal: J Pathol Date: 2005-12 Impact factor: 7.996
Authors: A Quaglia; J Tibballs; A Grasso; N Prasad; P Nozza; S E Davies; A K Burroughs; A Watkinson; A P Dhillon Journal: Histopathology Date: 2003-01 Impact factor: 5.087
Authors: Maarten G Thomeer; Mirelle E E Bröker; Quido de Lussanet; Katharina Biermann; Roy S Dwarkasing; Rob de Man; Jan N Ijzermans; Marianne de Vries Journal: Diagn Interv Radiol Date: 2014 May-Jun Impact factor: 2.630