Literature DB >> 2261823

Effect of captopril on glucose concentration. Possible role of augmented postprandial forearm blood flow.

J Kodama1, S Katayama, K Tanaka, A Itabashi, S Kawazu, J Ishii.   

Abstract

The goal of this study was to evaluate the effects of captopril on plasma glucose concentration. The daily profiles of the plasma glucose levels were determined in 12 non-insulin-dependent diabetic normotensive subjects, treated with or without captopril at a dose of 25 mg 3 times/day. Forearm blood flow was also measured by strain-gauge plethysmography. Administration of captopril improved the daily profile of the plasma glucose level. Postprandial forearm blood flow was also augmented 2 h after a meal. These results suggest that angiotensin-converting enzyme inhibitors may improve glucose metabolism in diabetic subjects, possibly through enhancement of blood flow to skeletal muscle.

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Year:  1990        PMID： 2261823     DOI： 10.2337/diacare.13.11.1109

Source DB:  PubMed          Journal:  Diabetes Care        ISSN： 0149-5992            Impact factor:   19.112


  17 in total

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