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Literature DB >> 22617426

Transcription: another mark in the tail.

Abstract

The C-terminal domain (CTD) of the largest RNA polymerase II (RNAPII) subunit undergoes dynamic phosphorylation to support transcription-associated events and drive the transcription cycle. In mammalian cells, it comprises 52 repeats of the heptapeptide sequence Tyr(1)–Ser(2)–Pro(3)–Thr(4)–Ser(5)–Pro(6)–Ser(7). While important functions for Ser(2)-, Ser(5)-, and Ser(7)-phosphorylation have previously been described, a new report in The EMBO Journal now suggests an unexpectedly crucial role for Thr(4) phosphorylation as well.

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Year: 2012 PMID： 22617426 PMCID： PMC3380221 DOI： 10.1038/emboj.2012.154

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

12 in total

1. Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product.

Authors: R Baskaran; G G Chiang; T Mysliwiec; G D Kruh; J Y Wang
Journal: J Biol Chem Date: 1997-07-25 Impact factor: 5.157

Review 2. Structure of eukaryotic RNA polymerases.

Authors: P Cramer; K-J Armache; S Baumli; S Benkert; F Brueckner; C Buchen; G E Damsma; S Dengl; S R Geiger; A J Jasiak; A Jawhari; S Jennebach; T Kamenski; H Kettenberger; C-D Kuhn; E Lehmann; K Leike; J F Sydow; A Vannini
Journal: Annu Rev Biophys Date: 2008 Impact factor: 12.981

3. Level of the RNA polymerase II in the fission yeast stays constant but phosphorylation of its carboxyl terminal domain varies depending on the phase and rate of cell growth.

Authors: Hitomi Sakurai; Akira Ishihama
Journal: Genes Cells Date: 2002-03 Impact factor: 1.891

4. RNA polymerase II C-terminal domain required for enhancer-driven transcription.

Authors: H P Gerber; M Hagmann; K Seipel; O Georgiev; M A West; Y Litingtung; W Schaffner; J L Corden
Journal: Nature Date: 1995-04-13 Impact factor: 49.962

5. Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.

Authors: Corinna Hintermair; Martin Heidemann; Frederic Koch; Nicolas Descostes; Marta Gut; Ivo Gut; Romain Fenouil; Pierre Ferrier; Andrew Flatley; Elisabeth Kremmer; Rob D Chapman; Jean-Christophe Andrau; Dirk Eick
Journal: EMBO J Date: 2012-05-01 Impact factor: 11.598

Transcription: another mark in the tail.

1. Tyrosine phosphorylation of RNA polymerase II carboxyl-terminal domain by the Abl-related gene product.

Review 2. Structure of eukaryotic RNA polymerases.

3. Level of the RNA polymerase II in the fission yeast stays constant but phosphorylation of its carboxyl terminal domain varies depending on the phase and rate of cell growth.

4. RNA polymerase II C-terminal domain required for enhancer-driven transcription.

5. Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.

6. The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain.

7. Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

Review 8. Progression through the RNA polymerase II CTD cycle.

Review 9. "Cotranscriptionality": the transcription elongation complex as a nexus for nuclear transactions.

10. Functional unit of the RNA polymerase II C-terminal domain lies within heptapeptide pairs.

Review 1. Nutrient regulation of signaling and transcription.

Review 2. Tyrosine-1 and threonine-4 phosphorylation marks complete the RNA polymerase II CTD phospho-code.

Review 3. Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II.