| Literature DB >> 22617290 |
Mingzhou Li1, Honglong Wu, Zonggang Luo, Yudong Xia, Jiuqiang Guan, Tao Wang, Yiren Gu, Lei Chen, Kai Zhang, Jideng Ma, Yingkai Liu, Zhijun Zhong, Jing Nie, Shuling Zhou, Zhiping Mu, Xiaoyan Wang, Jingjing Qu, Long Jing, Huiyu Wang, Shujia Huang, Na Yi, Zhe Wang, Dongxing Xi, Juan Wang, Guangliang Yin, Li Wang, Ning Li, Zhi Jiang, Qiulei Lang, Huasheng Xiao, Anan Jiang, Li Zhu, Yanzhi Jiang, Guoqing Tang, Miaomiao Mai, Surong Shuai, Ning Li, Kui Li, Jinyong Wang, Xiuqing Zhang, Yingrui Li, Haosi Chen, Xiaolian Gao, Graham S Plastow, Stephen Beck, Huanming Yang, Jian Wang, Jun Wang, Xuewei Li, Ruiqiang Li.
Abstract
It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct skeletal muscle tissues from three pig breeds living within comparable environments but displaying distinct fat level. We generate 1,381 Gb of sequence data from 180 methylated DNA immunoprecipitation libraries, and provide a genome-wide DNA methylation map as well as a gene expression map for adipose and muscle studies. The analysis shows global similarity and difference among breeds, sexes and anatomic locations, and identifies the differentially methylated regions. The differentially methylated regions in promoters are highly associated with obesity development via expression repression of both known obesity-related genes and novel genes. This comprehensive map provides a solid basis for exploring epigenetic mechanisms of adipose deposition and muscle growth.Entities:
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Year: 2012 PMID： 22617290 PMCID： PMC3508711 DOI： 10.1038/ncomms1854
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919