Literature DB >> 22614955

Transient focal cerebral ischemia upregulates immunoproteasomal subunits.

Lanhai Lü1, Hongmin Wang.   

Abstract

This study was designed to determine whether focal cerebral ischemia alters the expression of the immunoproteasomal (i-proteasomal) subunits. Transient cerebral ischemia significantly increased the expression of the i-proteasomal subunits, 20S β1i (LMP2) and β5i (LMP7) in the parietal cortex and hippocampus. This alteration was associated with a remarkable increase in ubiquitinated proteins. It is likely that the postischemic induction of the i-proteasome plays an important role in coping with the damaged proteins and thus may have an important effect on neuronal survival and death.

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Year:  2012        PMID： 22614955     DOI： 10.1007/s10571-012-9854-y

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  13 in total

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Journal:  Neurobiol Aging       Date:  2006-01       Impact factor: 4.673

4.  Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.

Authors:  Dmitriy N Atochin; Jeffrey Clark; Ivan T Demchenko; Michael A Moskowitz; Paul L Huang
Journal:  Stroke       Date:  2003-04-03       Impact factor: 7.914

5.  Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.

Authors:  Gaofeng Dong; Eduardo A Callegari; Christian J Gloeckner; Marius Ueffing; Hongmin Wang
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6.  Changes in proteasome activity following transient ischemia.

Authors:  T Kamikubo; T Hayashi
Journal:  Neurochem Int       Date:  1996-02       Impact factor: 3.921

7.  Pyrrolidine dithiocarbamate inhibits induction of immunoproteasome and decreases survival in a rat model of amyotrophic lateral sclerosis.

Authors:  Toni Ahtoniemi; Gundars Goldsteins; Velta Keksa-Goldsteine; Tarja Malm; Katja Kanninen; Antero Salminen; Jari Koistinaho
Journal:  Mol Pharmacol       Date:  2006-09-28       Impact factor: 4.436

8.  Protein aggregation and proteasome dysfunction after brain ischemia.

Authors:  Pengfei Ge; Yinan Luo; Cindy L Liu; Bingren Hu
Journal:  Stroke       Date:  2007-11-01       Impact factor: 7.914

9.  Post-transient ischemia increase in ubiquitin conjugates in the early reperfusion.

Authors:  T Hayashi; K Takada; M Matsuda
Journal:  Neuroreport       Date:  1992-06       Impact factor: 1.837

10.  Transient middle cerebral artery occlusion induces microglial priming in the lumbar spinal cord: a novel model of neuroinflammation.

Authors:  Katie Moisse; Ian Welch; Tracy Hill; Kathryn Volkening; Michael J Strong
Journal:  J Neuroinflammation       Date:  2008-07-07       Impact factor: 8.322
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  15 in total

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2.  Enhanced Proteostasis in Post-ischemic Stroke Mouse Brains by Ubiquilin-1 Promotes Functional Recovery.

Authors:  Yanying Liu; Fangfang Qiao; Hongmin Wang
Journal:  Cell Mol Neurobiol       Date:  2016-12-07       Impact factor: 5.046

3.  USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice.

Authors:  Jia-Wei Min; Lanhai Lü; Jessica L Freeling; Doug S Martin; Hongmin Wang
Journal:  J Neurochem       Date:  2017-01-26       Impact factor: 5.372

4.  Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice.

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Review 5.  The ubiquitin proteasome system and myocardial ischemia.

Authors:  Justine Calise; Saul R Powell
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6.  The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model.

Authors:  Yanying Liu; Casey L Hettinger; Dong Zhang; Khosrow Rezvani; Xuejun Wang; Hongmin Wang
Journal:  Cell Mol Neurobiol       Date:  2013-12-21       Impact factor: 5.046

7.  PR-957 mediates neuroprotection by inhibiting Th17 differentiation and modulating cytokine production in a mouse model of ischaemic stroke.

Authors:  Y Guo; X Chen; D Li; H Liu; Y Ding; R Han; Y Shi; X Ma
Journal:  Clin Exp Immunol       Date:  2018-04-23       Impact factor: 4.330

8.  Inhibition of immunoproteasome reduces infarction volume and attenuates inflammatory reaction in a rat model of ischemic stroke.

Authors:  X Chen; X Zhang; Y Wang; H Lei; H Su; J Zeng; Z Pei; R Huang
Journal:  Cell Death Dis       Date:  2015-01-29       Impact factor: 8.469

9.  Reduced body weight gain in ubiquilin-1 transgenic mice is associated with increased expression of energy-sensing proteins.

Authors:  Fangfang Qiao; Kirsty R Longley; Shelley Feng; Sabrina Schnack; Hongbo Gao; Yifan Li; Evelyn H Schlenker; Hongmin Wang
Journal:  Physiol Rep       Date:  2017-04

Review 10.  Proteasome and Organs Ischemia-Reperfusion Injury.

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Journal:  Int J Mol Sci       Date:  2017-12-30       Impact factor: 5.923
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