Literature DB >> 22614927

The role of astrocytic glycogen in supporting the energetics of neuronal activity.

Mauro Dinuzzo1, Silvia Mangia, Bruno Maraviglia, Federico Giove.   

Abstract

Energy homeostasis in the brain is maintained by oxidative metabolism of glucose, primarily to fulfil the energy demand associated with ionic movements in neurons and astrocytes. In this contribution we review the experimental evidence that grounds a specific role of glycogen metabolism in supporting the functional energetic needs of astrocytes during the removal of extracellular potassium. Based on theoretical considerations, we further discuss the hypothesis that the mobilization of glycogen in astrocytes serves the purpose to enhance the availability of glucose for neuronal glycolytic and oxidative metabolism at the onset of stimulation. Finally, we provide an evolutionary perspective for explaining the selection of glycogen as carbohydrate reserve in the energy-sensing machinery of cell metabolism.

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Year:  2012        PMID： 22614927      PMCID： PMC4062197          DOI： 10.1007/s11064-012-0802-5

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  66 in total

1.  Implication of Kir4.1 channel in excess potassium clearance: an in vivo study on anesthetized glial-conditional Kir4.1 knock-out mice.

Authors:  Oana Chever; Biljana Djukic; Ken D McCarthy; Florin Amzica
Journal:  J Neurosci       Date:  2010-11-24       Impact factor: 6.167

2.  A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor.

Authors:  Y Hu; G S Wilson
Journal:  J Neurochem       Date:  1997-10       Impact factor: 5.372

3.  Pharmacological characteristics of potassium-induced, glycogenolysis in astrocytes.

Authors:  K V Subbarao; J U Stolzenburg; L Hertz
Journal:  Neurosci Lett       Date:  1995-08-18       Impact factor: 3.046

4.  [Interaction between glycogen phosphorylase b and creatinine kinase from rabbit skeletal muscle].

Authors:  A K Khakimova; L K Skolysheva; S A Shur; I L Vul'fson
Journal:  Biokhimiia       Date:  1995-02

5.  Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: dynamic responses to depolarization and sensitivity to pioglitazone.

Authors:  Tristano Pancani; Katie L Anderson; Nada M Porter; Olivier Thibault
Journal:  Cell Calcium       Date:  2011-10-05       Impact factor: 6.817

6.  Acute and chronic effects of potassium and noradrenaline on Na+, K+-ATPase activity in cultured mouse neurons and astrocytes.

Authors:  I Hajek; K V Subbarao; L Hertz
Journal:  Neurochem Int       Date:  1996-03       Impact factor: 3.921

7.  Tissue- and isoform-specific kinetic behavior of the Na,K-ATPase.

Authors:  J S Munzer; S E Daly; E A Jewell-Motz; J B Lingrel; R Blostein
Journal:  J Biol Chem       Date:  1994-06-17       Impact factor: 5.157

8.  Evolution of allosteric control in glycogen phosphorylase.

Authors:  J W Hudson; G B Golding; M M Crerar
Journal:  J Mol Biol       Date:  1993-12-05       Impact factor: 5.469

9.  Regulatory role of a neurotransmitter (5-HT) on glial Na+/K(+)-ATPase in the rat brain.

Authors:  R Mercado; J Hernández
Journal:  Neurochem Int       Date:  1992-07       Impact factor: 3.921

10.  Comparative analysis of species-independent, isozyme-specific amino-acid substitutions in mammalian muscle, brain and liver glycogen phosphorylases.

Authors:  J W Hudson; K L Hefferon; M M Crerar
Journal:  Biochim Biophys Acta       Date:  1993-07-10
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  41 in total

Review 1.  Astrocytic energetics during excitatory neurotransmission: What are contributions of glutamate oxidation and glycolysis?

Authors:  Gerald A Dienel
Journal:  Neurochem Int       Date:  2013-07-06       Impact factor: 3.921

2.  Kinetic analysis of glycogen turnover: relevance to human brain 13C-NMR spectroscopy.

Authors:  Mauro DiNuzzo
Journal:  J Cereb Blood Flow Metab       Date:  2013-06-12       Impact factor: 6.200

3.  How does fasting trigger migraine? A hypothesis.

Authors:  Turgay Dalkara; Kivilcim Kiliç
Journal:  Curr Pain Headache Rep       Date:  2013-10

Review 4.  Role of the Astrocytic Na(+), K(+)-ATPase in K(+) Homeostasis in Brain: K(+) Uptake, Signaling Pathways and Substrate Utilization.

Authors:  Leif Hertz; Dan Song; Junnan Xu; Liang Peng; Marie E Gibbs
Journal:  Neurochem Res       Date:  2015-01-03       Impact factor: 3.996

5.  Dynamic Changes in Cytosolic ATP Levels in Cultured Glutamatergic Neurons During NMDA-Induced Synaptic Activity Supported by Glucose or Lactate.

Authors:  Sofie C Lange; Ulrike Winkler; Lars Andresen; Mathilde Byhrø; Helle S Waagepetersen; Johannes Hirrlinger; Lasse K Bak
Journal:  Neurochem Res       Date:  2015-07-17       Impact factor: 3.996

Review 6.  How glycogen sustains brain function: A plausible allosteric signaling pathway mediated by glucose phosphates.

Authors:  Mauro DiNuzzo
Journal:  J Cereb Blood Flow Metab       Date:  2019-06-17       Impact factor: 6.200

7.  Food For Thought: Short-Term Fasting Upregulates Glucose Transporters in Neurons and Endothelial Cells, But Not in Astrocytes.

Authors:  Tamara Dakic; Tanja Jevdjovic; Iva Lakic; Sinisa F Djurasevic; Jelena Djordjevic; Predrag Vujovic
Journal:  Neurochem Res       Date:  2018-11-20       Impact factor: 3.996

8.  Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis.

Authors:  Dhaval P Bhatt; Heidi M Houdek; John A Watt; Thad A Rosenberger
Journal:  Neurochem Int       Date:  2013-01-12       Impact factor: 3.921

Review 9.  Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy.

Authors:  Mauro DiNuzzo; Silvia Mangia; Bruno Maraviglia; Federico Giove
Journal:  Epilepsy Res       Date:  2014-04-21       Impact factor: 3.045

Review 10.  Metabolic pathways and activity-dependent modulation of glutamate concentration in the human brain.

Authors:  Silvia Mangia; Federico Giove; Mauro Dinuzzo
Journal:  Neurochem Res       Date:  2012-07-31       Impact factor: 3.996
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