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Literature DB >> 1303137

Regulatory role of a neurotransmitter (5-HT) on glial Na+/K(+)-ATPase in the rat brain.

Abstract

In the present work we studied the effect of serotonin (5-HT) on the kinetics of Na+/K(+)-ATPase in subcellular preparations of the cerebral cortex from male Wistar rats using various concentrations of ATP and K+ with and without added 5-HT. Also we studied the effect of 5-HT on the enzyme in glial or neuronal preparations. The results indicated that there was a significant increase (P < 0.05) of the Vmax in the presence of 5-HT in the whole tissue preparation (homogenate) but not in the subcellular fractions, suggesting that the interaction could be preferentially with the glial pump. Further results supported that this was the case since activation by 5-HT was mainly in the glial preparations. Kinetic data and the binding of [3H]ouabain supported that the enzyme is activated by 5-HT through the exposure of more enzymatic active sites.

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Year: 1992 PMID： 1303137 DOI： 10.1016/0197-0186(92)90074-2

Source DB: PubMed Journal: Neurochem Int ISSN： 0197-0186 Impact factor: 3.921

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Cited

6 in total

6. Astrocytic and neuronal accumulation of elevated extracellular K(+) with a 2/3 K(+)/Na(+) flux ratio-consequences for energy metabolism, osmolarity and higher brain function.

Authors: Leif Hertz; Junnan Xu; Dan Song; Enzhi Yan; Li Gu; Liang Peng
Journal: Front Comput Neurosci Date: 2013-08-22 Impact factor: 2.380

6 in total

Regulatory role of a neurotransmitter (5-HT) on glial Na+/K(+)-ATPase in the rat brain.

1. Regulation of glial Na+/K+-ATPase by serotonin: identification of participating receptors.

Review 2. The role of astrocytic glycogen in supporting the energetics of neuronal activity.

Review 3. Monoaminergic Control of Cellular Glucose Utilization by Glycogenolysis in Neocortex and Hippocampus.

4. Serotonin modulation of low-affinity ouabain binding in rat brain determined by quantitative autoradiography.

5. Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons.

6. Astrocytic and neuronal accumulation of elevated extracellular K(+) with a 2/3 K(+)/Na(+) flux ratio-consequences for energy metabolism, osmolarity and higher brain function.