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Literature DB >> 22614003

Chromosomal instability and aneuploidy in cancer: from yeast to man.

Abstract

Aneuploidy is frequently associated with disease and developmental abnormalities. It is also a key characteristic of cancer. Several model systems have been developed to study the role of chromosomal instability and aneuploidy in tumorigenesis. The results are surprisingly complex, with the conditions sometimes promoting and sometimes inhibiting tumour formation. Here, we review the effects of aneuploidy and chromosomal instability in cells and model systems of cancer, propose a model that could explain these complex findings and discuss how the aneuploid condition could be exploited in cancer therapy.

Entities: Disease Species

Mesh：

Substances：

Year: 2012 PMID： 22614003 PMCID： PMC3367249 DOI： 10.1038/embor.2012.65

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

115 in total

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Authors: A Plaja; C Perez; R Miró
Journal: Cancer Genet Cytogenet Date: 2001-12

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Journal: Proc Natl Acad Sci U S A Date: 2001-11-06 Impact factor: 11.205

Review 3. From polyploidy to aneuploidy, genome instability and cancer.

Authors: Zuzana Storchova; David Pellman
Journal: Nat Rev Mol Cell Biol Date: 2004-01 Impact factor: 94.444

Review 4. Variegated aneuploidy related to premature centromere division (PCD) is expressed in vivo and is a cancer-prone disease.

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Journal: Am J Med Genet Date: 2001-01-22

5. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells.

Authors: L S Michel; V Liberal; A Chatterjee; R Kirchwegger; B Pasche; W Gerald; M Dobles; P K Sorger; V V Murty; R Benezra
Journal: Nature Date: 2001-01-18 Impact factor: 49.962

Review 6. Dosage-dependent gene regulation in multicellular eukaryotes: implications for dosage compensation, aneuploid syndromes, and quantitative traits.

Authors: J A Birchler; U Bhadra; M P Bhadra; D L Auger
Journal: Dev Biol Date: 2001-06-15 Impact factor: 3.582

7. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.

Authors: D A Tuveson; N A Willis; T Jacks; J D Griffin; S Singer; C D Fletcher; J A Fletcher; G D Demetri
Journal: Oncogene Date: 2001-08-16 Impact factor: 9.867

8. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

Authors: B J Druker; M Talpaz; D J Resta; B Peng; E Buchdunger; J M Ford; N B Lydon; H Kantarjian; R Capdeville; S Ohno-Jones; C L Sawyers
Journal: N Engl J Med Date: 2001-04-05 Impact factor: 91.245

9. Molecular cytogenetic analysis of breast cancer: a combined multicolor fluorescence in situ hybridization and G-banding study of uncultured tumor cells.

Authors: Angeliki D Ferti; Maria J Stamouli; Anna D Panani; Sotirios A Raptis; Bryan D Young
Journal: Cancer Genet Cytogenet Date: 2004-02

10. Molecular cytogenetic analysis of breast cancer cell lines.

Authors: J M Davidson; K L Gorringe; S F Chin; B Orsetti; C Besret; C Courtay-Cahen; I Roberts; C Theillet; C Caldas; P A Edwards
Journal: Br J Cancer Date: 2000-11 Impact factor: 7.640

98 in total

1. Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.

Authors: Yun-Chi Tang; Hui Yuwen; Kaiying Wang; Peter M Bruno; Kevin Bullock; Amy Deik; Stefano Santaguida; Marianna Trakala; Sarah J Pfau; Na Zhong; Tao Huang; Lan Wang; Clary B Clish; Michael T Hemann; Angelika Amon
Journal: Cancer Res Date: 2017-08-03 Impact factor: 12.701

Review 2. Centrosomes in spindle organization and chromosome segregation: a mechanistic view.

Authors: Patrick Meraldi
Journal: Chromosome Res Date: 2016-01 Impact factor: 5.239

3. High-throughput analysis of yeast replicative aging using a microfluidic system.

Authors: Myeong Chan Jo; Wei Liu; Liang Gu; Weiwei Dang; Lidong Qin
Journal: Proc Natl Acad Sci U S A Date: 2015-07-13 Impact factor: 11.205

4. Xenopatients 2.0: reprogramming the epigenetic landscapes of patient-derived cancer genomes.

Authors: Javier A Menendez; Tomás Alarcón; Bruna Corominas-Faja; Elisabet Cuyàs; Eugeni López-Bonet; Angel G Martin; Luciano Vellon
Journal: Cell Cycle Date: 2014-01-09 Impact factor: 4.534

5. The COMA complex interacts with Cse4 and positions Sli15/Ipl1 at the budding yeast inner kinetochore.

Authors: Josef Fischböck-Halwachs; Sylvia Singh; Mia Potocnjak; Götz Hagemann; Victor Solis-Mezarino; Stephan Woike; Medini Ghodgaonkar-Steger; Florian Weissmann; Laura D Gallego; Julie Rojas; Jessica Andreani; Alwin Köhler; Franz Herzog
Journal: Elife Date: 2019-05-21 Impact factor: 8.140

Review 6. Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics.

Authors: Cayetano Gonzalez
Journal: Nat Rev Cancer Date: 2013-02-07 Impact factor: 60.716

7. Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing.

Authors: Veronika Butin-Israeli; Triet M Bui; Hannah L Wiesolek; Lorraine Mascarenhas; Joseph J Lee; Lindsey C Mehl; Kaitlyn R Knutson; Stephen A Adam; Robert D Goldman; Arthur Beyder; Lisa Wiesmuller; Stephen B Hanauer; Ronen Sumagin
Journal: J Clin Invest Date: 2019-01-14 Impact factor: 14.808