Literature DB >> 22613038

Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules.

Leonid Vigderman1, Eugene R Zubarev.   

Abstract

This review will first look at the various covalent strategies that have been developed to attach drugs to gold nanoparticles as well as the strengths and limitations of such strategies. After examining general strategies for the synthesis of gold nanoparticles and their subsequent covalent functionalization, this review will focus on nanoparticle conjugates for gene therapy, antibacterial, and anticancer applications including the use of gold nanoparticles with intrinsically therapeutic properties. The effects of targeting and cellular uptake of gold nanoparticles will also be discussed.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22613038     DOI： 10.1016/j.addr.2012.05.004

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  56 in total

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