Literature DB >> 22610946

Role of dopamine receptors in ADHD: a systematic meta-analysis.

Jing Wu1, Haifan Xiao, Hongjuan Sun, Li Zou, Ling-Qiang Zhu.   

Abstract

The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1-D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.

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Year:  2012        PMID： 22610946     DOI： 10.1007/s12035-012-8278-5

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  217 in total

1.  Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study.

Authors:  A Payton; J Holmes; J H Barrett; T Hever; H Fitzpatrick; A L Trumper; R Harrington; P McGuffin; M O'Donovan; M Owen; W Ollier; J Worthington; A Thapar
Journal:  Am J Med Genet       Date:  2001-07-08

2.  Distribution of D2 dopamine receptor mRNA in rat brain.

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Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

Review 3.  A neural substrate of prediction and reward.

Authors:  W Schultz; P Dayan; P R Montague
Journal:  Science       Date:  1997-03-14       Impact factor: 47.728

4.  In vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of D5 receptors in rats.

Authors:  E M Apostolakis; J Garai; J H Clark; B W O'Malley
Journal:  Mol Endocrinol       Date:  1996-12

Review 5.  Amphetamine: effects on catecholamine systems and behavior.

Authors:  L S Seiden; K E Sabol; G A Ricaurte
Journal:  Annu Rev Pharmacol Toxicol       Date:  1993       Impact factor: 13.820

6.  A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia.

Authors:  Y Okuyama; H Ishiguro; M Toru; T Arinami
Journal:  Biochem Biophys Res Commun       Date:  1999-05-10       Impact factor: 3.575

7.  A case-control association study of the polymorphism at the promoter region of the DRD4 gene in Korean boys with attention deficit-hyperactivity disorder: evidence of association with the -521 C/T SNP.

Authors:  Jae-Won Yang; Won-Seok Jang; Sungdo David Hong; Yong Ick Ji; Duk Hwan Kim; Jubae Park; Swon Woo Kim; Yoo Sook Joung
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2007-08-22       Impact factor: 5.067

8.  Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children.

Authors:  Eva Kereszturi; Zsanett Tarnok; Emese Bognar; Krisztina Lakatos; Luca Farkas; Julia Gadoros; Maria Sasvari-Szekely; Zsofia Nemoda
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2008-12-05       Impact factor: 3.568

9.  Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status.

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Journal:  Arch Gen Psychiatry       Date:  1993-07

10.  Association of a duplicated repeat polymorphism in the 5'-untranslated region of the DRD4 gene with novelty seeking.

Authors:  Geraldine Rogers; Peter Joyce; Roger Mulder; Douglas Sellman; Allison Miller; Melanie Allington; Robin Olds; Elisabeth Wells; Martin Kennedy
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2004-04-01       Impact factor: 3.568
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  74 in total

1.  Serotonin transporter polymorphism moderates the effects of caregiver intrusiveness on ADHD symptoms among institutionalized preschoolers.

Authors:  Joana Baptista; Jay Belsky; Ana Mesquita; Isabel Soares
Journal:  Eur Child Adolesc Psychiatry       Date:  2016-07-18       Impact factor: 4.785

Review 2.  Neurobehavioral changes arising from early life dopamine signaling perturbations.

Authors:  Lorena B Areal; Randy D Blakely
Journal:  Neurochem Int       Date:  2020-04-20       Impact factor: 3.921

Review 3.  Age-related variability in decision-making: Insights from neurochemistry.

Authors:  Anne S Berry; William J Jagust; Ming Hsu
Journal:  Cogn Affect Behav Neurosci       Date:  2019-06       Impact factor: 3.282

Review 4.  ADHD, altered dopamine neurotransmission, and disrupted reinforcement processes: implications for smoking and nicotine dependence.

Authors:  Scott H Kollins; R Alison Adcock
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2014-02-18       Impact factor: 5.067

Review 5.  Fractionating impulsivity: neuropsychiatric implications.

Authors:  Jeffrey W Dalley; Trevor W Robbins
Journal:  Nat Rev Neurosci       Date:  2017-02-17       Impact factor: 34.870

Review 6.  Genetic Influence on Efficacy of Pharmacotherapy for Pediatric Attention-Deficit/Hyperactivity Disorder: Overview and Current Status of Research.

Authors:  Nada A Elsayed; Kaila M Yamamoto; Tanya E Froehlich
Journal:  CNS Drugs       Date:  2020-04       Impact factor: 5.749

7.  On deep history and pyschotropy.

Authors:  Benjamin Campbell
Journal:  Cult Med Psychiatry       Date:  2014-06

8.  Genetic associations between ADHD and dopaminergic genes (DAT1 and DRD4) VNTRs in Korean children.

Authors:  Jun Ho Hong; In Wook Hwang; Myung Ho Lim; Ho Jang Kwon; Han Jun Jin
Journal:  Genes Genomics       Date:  2018-08-11       Impact factor: 1.839

9.  Potential contribution of dopaminergic gene variants in ADHD core traits and co-morbidity: a study on eastern Indian probands.

Authors:  Subhamita Maitra; Kanyakumarika Sarkar; Paramita Ghosh; Arijit Karmakar; Animesh Bhattacharjee; Swagata Sinha; Kanchan Mukhopadhyay
Journal:  Cell Mol Neurobiol       Date:  2014-03-02       Impact factor: 5.046

10.  A Test-Replicate Approach to Candidate Gene Research on Addiction and Externalizing Disorders: A Collaboration Across Five Longitudinal Studies.

Authors:  Diana R Samek; Jennifer Bailey; Karl G Hill; Sylia Wilson; Susanne Lee; Margaret A Keyes; Marina Epstein; Andrew Smolen; Michael Miller; Ken C Winters; J David Hawkins; Richard F Catalano; William G Iacono; Matt McGue
Journal:  Behav Genet       Date:  2016-07-21       Impact factor: 2.805
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