Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Distribution of D2 dopamine receptor mRNA in rat brain.

Literature DB >> 2529545

Distribution of D2 dopamine receptor mRNA in rat brain.

J H Meador-Woodruff¹, A Mansour, J R Bunzow, H H Van Tol, S J Watson, O Civelli.

Abstract

The distribution of mRNA coding for the D2 dopamine receptor was studied in the rat brain by in situ hybridization. A cDNA probe corresponding to the putative third cytosolic loop and sixth and seventh transmembrane domains of the rat D2 receptor was used to generate an 35S-labeled riboprobe to hybridize to D2 receptor mRNA. D2 mRNA was found both in dopamine projection fields and in regions associated with dopamine-containing cell bodies, suggesting both postsynaptic and presynaptic autoreceptor localization. Highest concentrations of D2 mRNA were found in neostriatum, olfactory tubercle, substantia nigra, ventral tegmental area, and the nucleus accumbens. This distribution is consistent with those reported with D2 receptor autoradiography.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2529545 PMCID： PMC298119 DOI： 10.1073/pnas.86.19.7625

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

19 in total

Review 1. Dopamine-sensitive adenylyl cyclase: a receptor mechanism for dopamine.

Authors: J W Kebabian
Journal: Adv Biochem Psychopharmacol Date: 1978

2. Autoradiographic localization of dopamine D2 receptors in the rat brain using the new agonist [3H]N-0437.

Authors: J van der Weide; M Camps; A S Horn; J M Palacios
Journal: Neurosci Lett Date: 1987-12-29 Impact factor: 3.046

Review 3. Studies on the pharmacological properties of dopamine receptors in various areas of the central nervous system.

Authors: P F Spano; S Govoni; M Trabucchi
Journal: Adv Biochem Psychopharmacol Date: 1978

4. Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer's, Parkinson's, and Huntington's diseases.

Authors: P Seeman; N H Bzowej; H C Guan; C Bergeron; G P Reynolds; E D Bird; P Riederer; K Jellinger; W W Tourtellotte
Journal: Neuropsychopharmacology Date: 1987-12 Impact factor: 7.853

5. Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum.

Authors: J C Stoof; J W Kebabian
Journal: Nature Date: 1981-11-26 Impact factor: 49.962

6. Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas.

Authors: P De Camilli; D Macconi; A Spada
Journal: Nature Date: 1979-03-15 Impact factor: 49.962

7. Presynaptic dopamine autoreceptors control tyrosine hydroxylase activation in depolarized striatal dopaminergic terminals.

Authors: S el Mestikawy; J Glowinski; M Hamon
Journal: J Neurochem Date: 1986-01 Impact factor: 5.372

8. Bimodal distribution of dopamine receptor densities in brains of schizophrenics.

Authors: P Seeman; C Ulpian; C Bergeron; P Riederer; K Jellinger; E Gabriel; G P Reynolds; W W Tourtellotte
Journal: Science Date: 1984-08-17 Impact factor: 47.728

9. Comparative distribution of dopamine D-1 and D-2 receptors in the basal ganglia of turtles, pigeons, rats, cats, and monkeys.

Authors: E K Richfield; A B Young; J B Penney
Journal: J Comp Neurol Date: 1987-08-15 Impact factor: 3.215

10. Selective cortical infarction reduces [3H]sulpiride binding in rat caudate-putamen: autoradiographic evidence for presynaptic D2 receptors on corticostriate terminals.

Authors: F Filloux; T H Liu; C Y Hsu; M A Hunt; J K Wamsley
Journal: Synapse Date: 1988 Impact factor: 2.562

33 in total

1. Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes.

Authors: Marquis P Vawter; Simon Evans; Prabhakara Choudary; Hiroaki Tomita; Jim Meador-Woodruff; Margherita Molnar; Jun Li; Juan F Lopez; Rick Myers; David Cox; Stanley J Watson; Huda Akil; Edward G Jones; William E Bunney
Journal: Neuropsychopharmacology Date: 2004-02 Impact factor: 7.853

2. Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission.

Authors: R T Fremeau; G E Duncan; M G Fornaretto; A Dearry; J A Gingrich; G R Breese; M G Caron
Journal: Proc Natl Acad Sci U S A Date: 1991-05-01 Impact factor: 11.205

Distribution of D2 dopamine receptor mRNA in rat brain.

Review 1. Dopamine-sensitive adenylyl cyclase: a receptor mechanism for dopamine.

2. Autoradiographic localization of dopamine D2 receptors in the rat brain using the new agonist [3H]N-0437.

Review 3. Studies on the pharmacological properties of dopamine receptors in various areas of the central nervous system.

4. Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer's, Parkinson's, and Huntington's diseases.

5. Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum.

6. Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas.

7. Presynaptic dopamine autoreceptors control tyrosine hydroxylase activation in depolarized striatal dopaminergic terminals.

8. Bimodal distribution of dopamine receptor densities in brains of schizophrenics.

9. Comparative distribution of dopamine D-1 and D-2 receptors in the basal ganglia of turtles, pigeons, rats, cats, and monkeys.

10. Selective cortical infarction reduces [3H]sulpiride binding in rat caudate-putamen: autoradiographic evidence for presynaptic D2 receptors on corticostriate terminals.

1. Gender-specific gene expression in post-mortem human brain: localization to sex chromosomes.

2. Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission.

Review 3. The external globus pallidus: progress and perspectives.

Review 4. Control of prolactin secretion by excitatory amino acids.

5. DARPP-32 like protein in specific snail (Helix aspersa) neurones.

6. Chemical transmission between dopaminergic neuron pairs.

7. D1 and D2 dopamine receptor mRNA in rat brain.

8. Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood.

Review 9. Pharmacological and molecular basis for dopamine D-2 receptor diversity.

10. The number of cells expressing dopamine D2 receptor mRNA in rat brain caudate putamen is higher in oestrus.